Abstract
We identified two β-lactamase-positive enterococci. One strain was high-level (MIC, >2,000 μg/ml) gentamicin resistant; the other ws not (MIC, 12.5 μg/ml). β-Lactamase production was extrachromosomally mediated in both strains, and both strains showed an inoculum effect reversed by β-lactamase inhibitors. The strain lacking high-level gentamicin resistance showed synergistic killing with a combination of penicillin, clavulanic acid, and gentamicin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 122-124 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 32 |
| Issue number | 1 |
| State | Published - 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology (medical)
Cite this
Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis. / Patterson, Jan E; Masecar, B. L.; Zervos, M. J.
In: Antimicrobial Agents and Chemotherapy, Vol. 32, No. 1, 1988, p. 122-124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis
AU - Patterson, Jan E
AU - Masecar, B. L.
AU - Zervos, M. J.
PY - 1988
Y1 - 1988
N2 - We identified two β-lactamase-positive enterococci. One strain was high-level (MIC, >2,000 μg/ml) gentamicin resistant; the other ws not (MIC, 12.5 μg/ml). β-Lactamase production was extrachromosomally mediated in both strains, and both strains showed an inoculum effect reversed by β-lactamase inhibitors. The strain lacking high-level gentamicin resistance showed synergistic killing with a combination of penicillin, clavulanic acid, and gentamicin.
AB - We identified two β-lactamase-positive enterococci. One strain was high-level (MIC, >2,000 μg/ml) gentamicin resistant; the other ws not (MIC, 12.5 μg/ml). β-Lactamase production was extrachromosomally mediated in both strains, and both strains showed an inoculum effect reversed by β-lactamase inhibitors. The strain lacking high-level gentamicin resistance showed synergistic killing with a combination of penicillin, clavulanic acid, and gentamicin.
UR - http://www.scopus.com/inward/record.url?scp=0023832816&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023832816&partnerID=8YFLogxK
M3 - Article
C2 - 3126703
AN - SCOPUS:0023832816
VL - 32
SP - 122
EP - 124
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 1
ER -