Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis

J. Evans Patterson; B. L. Masecar; M. J. Zervos

doi:10.1128/aac.32.1.122

Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis

J. Evans Patterson, B. L. Masecar, M. J. Zervos

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We identified two β-lactamase-positive enterococci. One strain was high-level (MIC, >2,000 μg/ml) gentamicin resistant; the other ws not (MIC, 12.5 μg/ml). β-Lactamase production was extrachromosomally mediated in both strains, and both strains showed an inoculum effect reversed by β-lactamase inhibitors. The strain lacking high-level gentamicin resistance showed synergistic killing with a combination of penicillin, clavulanic acid, and gentamicin.

Original language	English (US)
Pages (from-to)	122-124
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	32
Issue number	1
DOIs	https://doi.org/10.1128/aac.32.1.122
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1128/aac.32.1.122

Fingerprint Dive into the research topics of 'Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis'. Together they form a unique fingerprint.

Cite this

@article{de02a7dcc61446928d6dcae25497de27,

title = "Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis",

abstract = "We identified two β-lactamase-positive enterococci. One strain was high-level (MIC, >2,000 μg/ml) gentamicin resistant; the other ws not (MIC, 12.5 μg/ml). β-Lactamase production was extrachromosomally mediated in both strains, and both strains showed an inoculum effect reversed by β-lactamase inhibitors. The strain lacking high-level gentamicin resistance showed synergistic killing with a combination of penicillin, clavulanic acid, and gentamicin.",

author = "{Evans Patterson}, J. and Masecar, {B. L.} and Zervos, {M. J.}",

year = "1988",

doi = "10.1128/aac.32.1.122",

language = "English (US)",

volume = "32",

pages = "122--124",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "1",

}

TY - JOUR

T1 - Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis

AU - Evans Patterson, J.

AU - Masecar, B. L.

AU - Zervos, M. J.

PY - 1988

Y1 - 1988

N2 - We identified two β-lactamase-positive enterococci. One strain was high-level (MIC, >2,000 μg/ml) gentamicin resistant; the other ws not (MIC, 12.5 μg/ml). β-Lactamase production was extrachromosomally mediated in both strains, and both strains showed an inoculum effect reversed by β-lactamase inhibitors. The strain lacking high-level gentamicin resistance showed synergistic killing with a combination of penicillin, clavulanic acid, and gentamicin.

AB - We identified two β-lactamase-positive enterococci. One strain was high-level (MIC, >2,000 μg/ml) gentamicin resistant; the other ws not (MIC, 12.5 μg/ml). β-Lactamase production was extrachromosomally mediated in both strains, and both strains showed an inoculum effect reversed by β-lactamase inhibitors. The strain lacking high-level gentamicin resistance showed synergistic killing with a combination of penicillin, clavulanic acid, and gentamicin.

UR - http://www.scopus.com/inward/record.url?scp=0023832816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023832816&partnerID=8YFLogxK

U2 - 10.1128/aac.32.1.122

DO - 10.1128/aac.32.1.122

M3 - Article

C2 - 3126703

AN - SCOPUS:0023832816

VL - 32

SP - 122

EP - 124

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 1

ER -