Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis

J. Evans Patterson; B. L. Masecar; M. J. Zervos

doi:10.1128/aac.32.1.122

Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis

J. Evans Patterson, B. L. Masecar, M. J. Zervos

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We identified two β-lactamase-positive enterococci. One strain was high-level (MIC, >2,000 μg/ml) gentamicin resistant; the other ws not (MIC, 12.5 μg/ml). β-Lactamase production was extrachromosomally mediated in both strains, and both strains showed an inoculum effect reversed by β-lactamase inhibitors. The strain lacking high-level gentamicin resistance showed synergistic killing with a combination of penicillin, clavulanic acid, and gentamicin.

Original language	English (US)
Pages (from-to)	122-124
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	32
Issue number	1
DOIs	https://doi.org/10.1128/aac.32.1.122
State	Published - 1988

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "We identified two β-lactamase-positive enterococci. One strain was high-level (MIC, >2,000 μg/ml) gentamicin resistant; the other ws not (MIC, 12.5 μg/ml). β-Lactamase production was extrachromosomally mediated in both strains, and both strains showed an inoculum effect reversed by β-lactamase inhibitors. The strain lacking high-level gentamicin resistance showed synergistic killing with a combination of penicillin, clavulanic acid, and gentamicin.",

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AB - We identified two β-lactamase-positive enterococci. One strain was high-level (MIC, >2,000 μg/ml) gentamicin resistant; the other ws not (MIC, 12.5 μg/ml). β-Lactamase production was extrachromosomally mediated in both strains, and both strains showed an inoculum effect reversed by β-lactamase inhibitors. The strain lacking high-level gentamicin resistance showed synergistic killing with a combination of penicillin, clavulanic acid, and gentamicin.

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