Abstract
This study was performed to define the characteristics of the relation between sodium delivery to and sodium reabsorption in the superficial loop of Henle (loop segment) and distal convoluted tubule (distal segment). This relation is examined in 3 experimental groups: when delivery was modestly increased with minimal changes in the extracellular fluid (ECF) volume; when delivery was significantly increased in association with acute progressive isotonic ECF volume expansion; and when delivery was significantly decreased by partial aortic constriction during progressive isotonic ECF volume expansion. In the loop segment, in all groups, absolute sodium reabsorption changed directly with sodium delivery, but the relation between delivery and absolute reabsorption was such that fractional reabsorption varied in inverse proportion to sodium delivery. In the 1st group the increases in delivery were minimal and absolute reabsorption in the distal segment paralleled delivery; fractional reabsorption remained constant. In the 2nd and 3rd group, absolute reabsorption varied directly but not proportionately with the large changes in delivery; fractional reabsorption therefore varied inversely to delivery. (28 references)
| Original language | English (US) |
|---|---|
| Title of host publication | American Journal of Physiology |
| Pages | 1181-1191 |
| Number of pages | 11 |
| Volume | 227 |
| Edition | 5 |
| State | Published - 1974 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Characteristics of sodium reabsorption in the loop of Henle and distal tubule. / Kunau, R. T.; Webb, H. L.; Borman, S. C.
American Journal of Physiology. Vol. 227 5. ed. 1974. p. 1181-1191.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Characteristics of sodium reabsorption in the loop of Henle and distal tubule
AU - Kunau, R. T.
AU - Webb, H. L.
AU - Borman, S. C.
PY - 1974
Y1 - 1974
N2 - This study was performed to define the characteristics of the relation between sodium delivery to and sodium reabsorption in the superficial loop of Henle (loop segment) and distal convoluted tubule (distal segment). This relation is examined in 3 experimental groups: when delivery was modestly increased with minimal changes in the extracellular fluid (ECF) volume; when delivery was significantly increased in association with acute progressive isotonic ECF volume expansion; and when delivery was significantly decreased by partial aortic constriction during progressive isotonic ECF volume expansion. In the loop segment, in all groups, absolute sodium reabsorption changed directly with sodium delivery, but the relation between delivery and absolute reabsorption was such that fractional reabsorption varied in inverse proportion to sodium delivery. In the 1st group the increases in delivery were minimal and absolute reabsorption in the distal segment paralleled delivery; fractional reabsorption remained constant. In the 2nd and 3rd group, absolute reabsorption varied directly but not proportionately with the large changes in delivery; fractional reabsorption therefore varied inversely to delivery. (28 references)
AB - This study was performed to define the characteristics of the relation between sodium delivery to and sodium reabsorption in the superficial loop of Henle (loop segment) and distal convoluted tubule (distal segment). This relation is examined in 3 experimental groups: when delivery was modestly increased with minimal changes in the extracellular fluid (ECF) volume; when delivery was significantly increased in association with acute progressive isotonic ECF volume expansion; and when delivery was significantly decreased by partial aortic constriction during progressive isotonic ECF volume expansion. In the loop segment, in all groups, absolute sodium reabsorption changed directly with sodium delivery, but the relation between delivery and absolute reabsorption was such that fractional reabsorption varied in inverse proportion to sodium delivery. In the 1st group the increases in delivery were minimal and absolute reabsorption in the distal segment paralleled delivery; fractional reabsorption remained constant. In the 2nd and 3rd group, absolute reabsorption varied directly but not proportionately with the large changes in delivery; fractional reabsorption therefore varied inversely to delivery. (28 references)
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UR - http://www.scopus.com/inward/citedby.url?scp=0016303252&partnerID=8YFLogxK
M3 - Chapter
C2 - 4440760
AN - SCOPUS:0016303252
VL - 227
SP - 1181
EP - 1191
BT - American Journal of Physiology
ER -