Characteristics of alkaline phosphatase from two continuous lines of human choriocarcinoma cells

K. V. Speeg, J. C. Azizkhan, K. Stromberg

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Abstract

Several characteristics of human choriocarcinoma alkaline phosphatase have been studied. BeWo and Jar choriocarcinoma lines each contain heat-stable alkaline phosphatase activity with characteristics similar to the D-variant term placental isoenzyme. The activity is also similar to the Nagao enzyme found in many malignancies. Each choriocarcinoma also has heat-labile alkaline phosphatase activity with characteristics similar to the enzyme found in normal first-trimester placenta. Neither BeWo alkaline phosphatase could be stimulated with cortisol. Both BeWo alkaline phosphatase activities could be stimulated with methotrexate and actinomycin D.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalExperimental Cell Research
Volume105
Issue number1
DOIs
Publication statusPublished - Mar 1 1977

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ASJC Scopus subject areas

  • Cell Biology

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