TY - CHAP
T1 - Chapter 2 Genetics of the Framingham Heart Study Population
AU - Govindaraju, Diddahally R.
AU - Adrienne Cupples, L.
AU - Kannel, William B.
AU - O'Donnell, Christopher J.
AU - Atwood, Larry D.
AU - D'Agostino, Ralph B.
AU - Fox, Caroline S.
AU - Larson, Marty
AU - Levy, Daniel
AU - Murabito, Joanne
AU - Vasan, Ramachandran S.
AU - Lee Splansky, Greta
AU - Wolf, Philip A.
AU - Benjamin, Emelia J.
PY - 2008
Y1 - 2008
N2 - This chapter provides an introduction to the Framingham Heart Study and the genetic research related to cardiovascular diseases conducted in this unique population. It briefly describes the origins of the study, the risk factors that contribute to heart disease, and the approaches taken to discover the genetic basis of some of these risk factors. The genetic architecture of several biological risk factors has been explained using family studies, segregation analysis, heritability, and phenotypic and genetic correlations. Many quantitative trait loci underlying cardiovascular diseases have been discovered using different molecular markers. Additionally, initial results from genome-wide association studies using 116,000 markers and the prospects of using 550,000 markers for association studies are presented. Finally, the use of this unique sample to study genotype and environment interactions is described.
AB - This chapter provides an introduction to the Framingham Heart Study and the genetic research related to cardiovascular diseases conducted in this unique population. It briefly describes the origins of the study, the risk factors that contribute to heart disease, and the approaches taken to discover the genetic basis of some of these risk factors. The genetic architecture of several biological risk factors has been explained using family studies, segregation analysis, heritability, and phenotypic and genetic correlations. Many quantitative trait loci underlying cardiovascular diseases have been discovered using different molecular markers. Additionally, initial results from genome-wide association studies using 116,000 markers and the prospects of using 550,000 markers for association studies are presented. Finally, the use of this unique sample to study genotype and environment interactions is described.
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UR - http://www.scopus.com/inward/citedby.url?scp=55749092742&partnerID=8YFLogxK
U2 - 10.1016/S0065-2660(08)00602-0
DO - 10.1016/S0065-2660(08)00602-0
M3 - Chapter
C2 - 19010253
AN - SCOPUS:55749092742
SN - 9780123744432
T3 - Advances in Genetics
SP - 33
EP - 65
BT - Advances in Genetics
A2 - Hall, Jeffrey
ER -