TY - JOUR
T1 - Changes occur in resting state network of motor system during 4weeks of motor skill learning
AU - Ma, Liangsuo
AU - Narayana, Shalini
AU - Robin, Donald A.
AU - Fox, Peter T.
AU - Xiong, Jinhu
PY - 2011/9/1
Y1 - 2011/9/1
N2 - We tested whether the resting state functional connectivity of the motor system changed during 4 weeks of motor skill learning using functional magnetic resonance imaging (fMRI). Ten healthy volunteers learned to produce a sequential finger movement by daily practice of the task over a 4 week period. Changes in the resting state motor network were examined before training (Week 0), two weeks after the onset of training (Week 2), and immediately at the end of the training (Week 4). The resting state motor system was analyzed using group independent component analysis (ICA). Statistical Parametric Mapping (SPM) second-level analysis was conducted on independent z-maps generated by the group ICA. Three regions, namely right postcentral gyrus, and bilateral supramarginal gyri were found to be sensitive to the training duration. Specifically, the strength of resting state functional connectivity in the right postcentral gyrus and right supramarginal gyrus increased from Week 0 to Week 2, during which the behavioral performance improved significantly, and decreased from Week 2 to Week 4, during which there was no more significant improvement in behavioral performance. The strength of resting state functional connectivity in left supramarginal gyrus increased throughout the training. These results confirm changes in the resting state network during slow-learning stage of motor skill learning, and support the premise that the resting state networks play a role in improving performance.
AB - We tested whether the resting state functional connectivity of the motor system changed during 4 weeks of motor skill learning using functional magnetic resonance imaging (fMRI). Ten healthy volunteers learned to produce a sequential finger movement by daily practice of the task over a 4 week period. Changes in the resting state motor network were examined before training (Week 0), two weeks after the onset of training (Week 2), and immediately at the end of the training (Week 4). The resting state motor system was analyzed using group independent component analysis (ICA). Statistical Parametric Mapping (SPM) second-level analysis was conducted on independent z-maps generated by the group ICA. Three regions, namely right postcentral gyrus, and bilateral supramarginal gyri were found to be sensitive to the training duration. Specifically, the strength of resting state functional connectivity in the right postcentral gyrus and right supramarginal gyrus increased from Week 0 to Week 2, during which the behavioral performance improved significantly, and decreased from Week 2 to Week 4, during which there was no more significant improvement in behavioral performance. The strength of resting state functional connectivity in left supramarginal gyrus increased throughout the training. These results confirm changes in the resting state network during slow-learning stage of motor skill learning, and support the premise that the resting state networks play a role in improving performance.
KW - ICA
KW - Independent component analysis
KW - Motor skill learning
KW - Resting state functional connectivity
KW - Resting state network
KW - Supramarginal gyrus
UR - http://www.scopus.com/inward/record.url?scp=79960649685&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960649685&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2011.06.014
DO - 10.1016/j.neuroimage.2011.06.014
M3 - Article
C2 - 21689765
AN - SCOPUS:79960649685
VL - 58
SP - 226
EP - 233
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 1
ER -