Abstract
Hepatic synthesis of α2u-globulin in the male rat begins at puberty (about 40 days), reaches a peak level at about 80 days, and ceases at about 750-800 days of age. The age-dependent changes in α2u-globulin synthesis are correlated with both the steady-state level of the hepatic mRNA for this protein and the rate of transcription of the α2u-globulin gene family. Transcriptional activation of the α2u-globulin gene family at puberty and cessation of transcription at senescence correlate with the association and dissociation of this gene domain with the nuclear matrix. Unlike the α2u-globulin gene, the albumin gene in the liver shows preferential association with the nuclear matrix throughout the life. From these results we conclude that the age-dependent changes in α2u-globulin synthesis are due to the alteration in the rate of transcription of the α2u-globulin gene, and that the association of this gene domain to the nuclear matrix is a prerequisite to its transcriptional activation.
Original language | English (US) |
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Pages (from-to) | 27-34 |
Number of pages | 8 |
Journal | BBA - Gene Structure and Expression |
Volume | 949 |
Issue number | 1 |
DOIs | |
State | Published - Jan 25 1988 |
Externally published | Yes |
Keywords
- (Rat liver)
- Aging
- Maturation
- Nuclear matrix
- Transcription
- α-Globulin gene family
ASJC Scopus subject areas
- Genetics
- Structural Biology
- Biophysics
- Biochemistry