Changes in transcriptional activity and matrix association of α2u-globulin gene family in the rat liver during maturation and aging

C. V.Ramana Murty, Michael A. Mancini, Bandana Chatterjee, Arun K. Roy

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Hepatic synthesis of α2u-globulin in the male rat begins at puberty (about 40 days), reaches a peak level at about 80 days, and ceases at about 750-800 days of age. The age-dependent changes in α2u-globulin synthesis are correlated with both the steady-state level of the hepatic mRNA for this protein and the rate of transcription of the α2u-globulin gene family. Transcriptional activation of the α2u-globulin gene family at puberty and cessation of transcription at senescence correlate with the association and dissociation of this gene domain with the nuclear matrix. Unlike the α2u-globulin gene, the albumin gene in the liver shows preferential association with the nuclear matrix throughout the life. From these results we conclude that the age-dependent changes in α2u-globulin synthesis are due to the alteration in the rate of transcription of the α2u-globulin gene, and that the association of this gene domain to the nuclear matrix is a prerequisite to its transcriptional activation.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalBBA - Gene Structure and Expression
Volume949
Issue number1
DOIs
StatePublished - Jan 25 1988
Externally publishedYes

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Keywords

  • (Rat liver)
  • Aging
  • Maturation
  • Nuclear matrix
  • Transcription
  • α-Globulin gene family

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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