Changes in the nuclear uptake and retention of 3H‐estrogen in gonadotrophs and lactotrophs as a function of age

H. Nogami, F. Yoshimura, D. C. Herbert, T. B. Aufdemorte, G. A. Gates, G. R. Holt, P. J. Sheridan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A quantitative autoradiographic immunocytochemical study was performed in which the nuclear uptake and retention of 3H‐estradiol (3H‐E2) by luteinizing hormone (LH) and prolactin (PRL) cells was examined in 19–21‐year‐old baboons. 3H‐E2 concentrating cells were found in all of the three lobes of the pituitary in varying percentages (38.7%, pars distalis; 17.1%, pars intermedia; 6.3%, pars nervosa). Approximately 80% of PRL cells and nearly 100% of LH cells were labeled. A count of the number of silver grains over nuclei revealed a marked variation of the accumulation of 3H‐E2 by LH cells and to a lesser extent in PRL cells. These results suggest functional heterogeneity among LH and PRL cells. The present results are discussed in relation to the physiological state of old animals.

Original languageEnglish (US)
Pages (from-to)288-291
Number of pages4
JournalThe Anatomical Record
Volume212
Issue number3
DOIs
StatePublished - Jul 1985

ASJC Scopus subject areas

  • Anatomy
  • Agricultural and Biological Sciences (miscellaneous)

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