Changes in the expression of superoxide dismutase and catalase as a function of age and dietary restriction

Imre Semsei, Govinda Rao, Arlan Richardson

Research output: Contribution to journalArticle

153 Scopus citations

Abstract

The activities of superoxide dismutase ( Cu Zn) and catalase were observed to decrease significantly between 6 and 29 months of age in rat liver. The decrease in superoxide dismutase and catalase activity was paralleled by a decrease in the levels of the mRNA species coding for these enzymes and the nuclear transcription of the superoxide dismutase and catalase genes. Life-long dietary restriction was shown to increase the expression (i.e. activities, mRNA levels, and nuclear transcription) of superoxide dismutase and catalase in liver tissue from 18-month-old rats.

Original languageEnglish (US)
Pages (from-to)620-625
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume164
Issue number2
DOIs
StatePublished - Oct 31 1989

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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