Changes in T-lymphocyte subsets during childhood Epstein-Barr virus infectious mononucleosis

Kristen A. Weigle, Ciro Valent Sumaya, Milka M. Montiel

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Lymphocyte subsets were measured using monoclonal antibodies in 11 children with Epstein-Barr virus-induced infectious mononucleosis and compared with those of 10 normal children. In acute infectious mononucleosis the percentage of T8+ lymphocytes was greater while the percentage of T4+ lymphocytes and the T4+ to T8+ ratio were less than those measured in normal children. The percentage and absolute number of T lymphocytes, as enumerated by E rosetting, did not differ from the values for normal children. The children with acute infectious mononucleosis had a somewhat lower T8+ response than that observed in four adult infectious mononucleosis patients. With clinical recovery, the T lymphocyte-subset values returned toward normal. T8+ lymphocytes, a phenotype subset with predominantly suppressor activity, presumably reduce normal cellular immune functions transiently and may limit the continued proliferation of Epstein-Barr virus-infected B lymphocytes.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalJournal of Clinical Immunology
Volume3
Issue number2
DOIs
StatePublished - Apr 1983
Externally publishedYes

Keywords

  • Epstein-Barr virus
  • infectious mononucleosis
  • lymphocyte subsets
  • suppressor T lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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