Changes in pineal indoleamine metabolism in vitamin a deficient rats

Damon C. Herbert, Russel J Reiter

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Weanling, male rats were fed a vitamin A deficient (VAD) diet from 20 to 77 days of age. The circadian rhythms of the precursors and metabolites of pineal melatonin were measured along with the activity of N-acetyltransferase (NAT). Significant decreases in peak melatonin levels (0100 hours) and in nightime NAT activity (0100 and 0300 hours) were found in the pineals of the VAD rats. In contrast, the contents of serotonin, 5-hydroxytryptophan and 5-hydroxyindole acetic acid were only moderately affected by the deficiency. Daily administration of 25 μg melatonin from 20 to 74 days of age markedly reduced NAT activity in control and VAD rats. These data suggest that NAT activity is more sensitive to chronic VAD than any other parameters of melatonin metabolism.

Original languageEnglish (US)
Pages (from-to)2515-2522
Number of pages8
JournalLife Sciences
Volume37
Issue number26
DOIs
StatePublished - Dec 30 1985
Externally publishedYes

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Acetyltransferases
Melatonin
Vitamin A
Metabolism
Vitamins
Rats
5-Hydroxytryptophan
Nutrition
Metabolites
Circadian Rhythm
Acetic Acid
Serotonin
Diet

ASJC Scopus subject areas

  • Pharmacology

Cite this

Changes in pineal indoleamine metabolism in vitamin a deficient rats. / Herbert, Damon C.; Reiter, Russel J.

In: Life Sciences, Vol. 37, No. 26, 30.12.1985, p. 2515-2522.

Research output: Contribution to journalArticle

Herbert, Damon C. ; Reiter, Russel J. / Changes in pineal indoleamine metabolism in vitamin a deficient rats. In: Life Sciences. 1985 ; Vol. 37, No. 26. pp. 2515-2522.
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