Changes in pineal indoleamine metabolism in vitamin a deficient rats

Damon C. Herbert; Russel J. Reiter

doi:10.1016/0024-3205(85)90609-5

Changes in pineal indoleamine metabolism in vitamin a deficient rats

Damon C. Herbert, Russel J. Reiter

Research output: Contribution to journal › Article › peer-review

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Abstract

Weanling, male rats were fed a vitamin A deficient (VAD) diet from 20 to 77 days of age. The circadian rhythms of the precursors and metabolites of pineal melatonin were measured along with the activity of N-acetyltransferase (NAT). Significant decreases in peak melatonin levels (0100 hours) and in nightime NAT activity (0100 and 0300 hours) were found in the pineals of the VAD rats. In contrast, the contents of serotonin, 5-hydroxytryptophan and 5-hydroxyindole acetic acid were only moderately affected by the deficiency. Daily administration of 25 μg melatonin from 20 to 74 days of age markedly reduced NAT activity in control and VAD rats. These data suggest that NAT activity is more sensitive to chronic VAD than any other parameters of melatonin metabolism.

Original language	English (US)
Pages (from-to)	2515-2522
Number of pages	8
Journal	Life Sciences
Volume	37
Issue number	26
DOIs	https://doi.org/10.1016/0024-3205(85)90609-5
State	Published - Dec 30 1985
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(85)90609-5

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title = "Changes in pineal indoleamine metabolism in vitamin a deficient rats",

abstract = "Weanling, male rats were fed a vitamin A deficient (VAD) diet from 20 to 77 days of age. The circadian rhythms of the precursors and metabolites of pineal melatonin were measured along with the activity of N-acetyltransferase (NAT). Significant decreases in peak melatonin levels (0100 hours) and in nightime NAT activity (0100 and 0300 hours) were found in the pineals of the VAD rats. In contrast, the contents of serotonin, 5-hydroxytryptophan and 5-hydroxyindole acetic acid were only moderately affected by the deficiency. Daily administration of 25 μg melatonin from 20 to 74 days of age markedly reduced NAT activity in control and VAD rats. These data suggest that NAT activity is more sensitive to chronic VAD than any other parameters of melatonin metabolism.",

author = "Herbert, {Damon C.} and Reiter, {Russel J.}",

note = "Funding Information: The authors wish to thank Valentina Golovko and Cathy Nichols for their technical assistance in the project. The work was supported by NSF grants PCM 8118487 (DCH) and PCM 841059? (RJR).",

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language = "English (US)",

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T1 - Changes in pineal indoleamine metabolism in vitamin a deficient rats

AU - Herbert, Damon C.

AU - Reiter, Russel J.

N1 - Funding Information: The authors wish to thank Valentina Golovko and Cathy Nichols for their technical assistance in the project. The work was supported by NSF grants PCM 8118487 (DCH) and PCM 841059? (RJR).

PY - 1985/12/30

Y1 - 1985/12/30

N2 - Weanling, male rats were fed a vitamin A deficient (VAD) diet from 20 to 77 days of age. The circadian rhythms of the precursors and metabolites of pineal melatonin were measured along with the activity of N-acetyltransferase (NAT). Significant decreases in peak melatonin levels (0100 hours) and in nightime NAT activity (0100 and 0300 hours) were found in the pineals of the VAD rats. In contrast, the contents of serotonin, 5-hydroxytryptophan and 5-hydroxyindole acetic acid were only moderately affected by the deficiency. Daily administration of 25 μg melatonin from 20 to 74 days of age markedly reduced NAT activity in control and VAD rats. These data suggest that NAT activity is more sensitive to chronic VAD than any other parameters of melatonin metabolism.

AB - Weanling, male rats were fed a vitamin A deficient (VAD) diet from 20 to 77 days of age. The circadian rhythms of the precursors and metabolites of pineal melatonin were measured along with the activity of N-acetyltransferase (NAT). Significant decreases in peak melatonin levels (0100 hours) and in nightime NAT activity (0100 and 0300 hours) were found in the pineals of the VAD rats. In contrast, the contents of serotonin, 5-hydroxytryptophan and 5-hydroxyindole acetic acid were only moderately affected by the deficiency. Daily administration of 25 μg melatonin from 20 to 74 days of age markedly reduced NAT activity in control and VAD rats. These data suggest that NAT activity is more sensitive to chronic VAD than any other parameters of melatonin metabolism.

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Changes in pineal indoleamine metabolism in vitamin a deficient rats

Abstract

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