Abstract
Changes in phagocytosis, chemotaxis, and nonspecific esterase staining of peritoneal exudate mononuclear cells occurred with aging in B6, AKR/J, and SJL/J mice. Different patterns of change with aging were observed with each of these three parameters in each of the strains. In the long-lived B6 mice, a progressive increase with aging in all three parameters was seen. In AKR/J mice, progressive increase in phagocytosis and nonspecific esterase staining was observed but a decline of chemotaxis occurred with aging. In SJL/J mice, all three parameters were very low early in life and each showed a significant increment upon reaching the age when the characteristic malignant lymphoreticular disease occurs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 227-234 |
| Number of pages | 8 |
| Journal | Cellular Immunology |
| Volume | 69 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 15 1982 |
ASJC Scopus subject areas
- Immunology
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Wustrow, T. P. U., Denny, T. N., Fernandes, G., & Good, R. A. (1982). Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice. Cellular Immunology, 69(2), 227-234. https://doi.org/10.1016/0008-8749(82)90069-7