Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice

T. P.U. Wustrow; T. N. Denny; G. Fernandes; R. A. Good

doi:10.1016/0008-8749(82)90069-7

Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice

T. P.U. Wustrow, T. N. Denny, G. Fernandes, R. A. Good

Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Changes in phagocytosis, chemotaxis, and nonspecific esterase staining of peritoneal exudate mononuclear cells occurred with aging in B6, AKR/J, and SJL/J mice. Different patterns of change with aging were observed with each of these three parameters in each of the strains. In the long-lived B6 mice, a progressive increase with aging in all three parameters was seen. In AKR/J mice, progressive increase in phagocytosis and nonspecific esterase staining was observed but a decline of chemotaxis occurred with aging. In SJL/J mice, all three parameters were very low early in life and each showed a significant increment upon reaching the age when the characteristic malignant lymphoreticular disease occurs.

Original language	English (US)
Pages (from-to)	227-234
Number of pages	8
Journal	Cellular Immunology
Volume	69
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(82)90069-7
State	Published - May 15 1982

ASJC Scopus subject areas

Immunology

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title = "Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice",

abstract = "Changes in phagocytosis, chemotaxis, and nonspecific esterase staining of peritoneal exudate mononuclear cells occurred with aging in B6, AKR/J, and SJL/J mice. Different patterns of change with aging were observed with each of these three parameters in each of the strains. In the long-lived B6 mice, a progressive increase with aging in all three parameters was seen. In AKR/J mice, progressive increase in phagocytosis and nonspecific esterase staining was observed but a decline of chemotaxis occurred with aging. In SJL/J mice, all three parameters were very low early in life and each showed a significant increment upon reaching the age when the characteristic malignant lymphoreticular disease occurs.",

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T1 - Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice

AU - Wustrow, T. P.U.

AU - Denny, T. N.

AU - Fernandes, G.

AU - Good, R. A.

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N2 - Changes in phagocytosis, chemotaxis, and nonspecific esterase staining of peritoneal exudate mononuclear cells occurred with aging in B6, AKR/J, and SJL/J mice. Different patterns of change with aging were observed with each of these three parameters in each of the strains. In the long-lived B6 mice, a progressive increase with aging in all three parameters was seen. In AKR/J mice, progressive increase in phagocytosis and nonspecific esterase staining was observed but a decline of chemotaxis occurred with aging. In SJL/J mice, all three parameters were very low early in life and each showed a significant increment upon reaching the age when the characteristic malignant lymphoreticular disease occurs.

AB - Changes in phagocytosis, chemotaxis, and nonspecific esterase staining of peritoneal exudate mononuclear cells occurred with aging in B6, AKR/J, and SJL/J mice. Different patterns of change with aging were observed with each of these three parameters in each of the strains. In the long-lived B6 mice, a progressive increase with aging in all three parameters was seen. In AKR/J mice, progressive increase in phagocytosis and nonspecific esterase staining was observed but a decline of chemotaxis occurred with aging. In SJL/J mice, all three parameters were very low early in life and each showed a significant increment upon reaching the age when the characteristic malignant lymphoreticular disease occurs.

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