Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice

T. P.U. Wustrow; T. N. Denny; G. Fernandes; R. A. Good

doi:10.1016/0008-8749(82)90069-7

Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice

T. P.U. Wustrow, T. N. Denny, G. Fernandes, R. A. Good

Research output: Contribution to journal › Article › peer-review

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Abstract

Changes in phagocytosis, chemotaxis, and nonspecific esterase staining of peritoneal exudate mononuclear cells occurred with aging in B6, AKR/J, and SJL/J mice. Different patterns of change with aging were observed with each of these three parameters in each of the strains. In the long-lived B6 mice, a progressive increase with aging in all three parameters was seen. In AKR/J mice, progressive increase in phagocytosis and nonspecific esterase staining was observed but a decline of chemotaxis occurred with aging. In SJL/J mice, all three parameters were very low early in life and each showed a significant increment upon reaching the age when the characteristic malignant lymphoreticular disease occurs.

Original language	English (US)
Pages (from-to)	227-234
Number of pages	8
Journal	Cellular Immunology
Volume	69
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(82)90069-7
State	Published - May 15 1982
Externally published	Yes

ASJC Scopus subject areas

Immunology

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@article{91f71d06af96447b8d3dc0fa5680cf4c,

title = "Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice",

abstract = "Changes in phagocytosis, chemotaxis, and nonspecific esterase staining of peritoneal exudate mononuclear cells occurred with aging in B6, AKR/J, and SJL/J mice. Different patterns of change with aging were observed with each of these three parameters in each of the strains. In the long-lived B6 mice, a progressive increase with aging in all three parameters was seen. In AKR/J mice, progressive increase in phagocytosis and nonspecific esterase staining was observed but a decline of chemotaxis occurred with aging. In SJL/J mice, all three parameters were very low early in life and each showed a significant increment upon reaching the age when the characteristic malignant lymphoreticular disease occurs.",

author = "Wustrow, {T. P.U.} and Denny, {T. N.} and G. Fernandes and Good, {R. A.}",

note = "Funding Information: {\textquoteright} Aided by grants from the Department of Health and Human Services, AG 00541, AG 02247, AI 11843, NS 11457, the Zelda Radow Weintraub Cancer Fund, the Richard Molin Foundation, and the Joe Brooks Fund. * Supported by the Deutsch Forschungsgmeinschaft Grant WU 111 /I. 3 To whom all correspondence should be sent at: Oklahoma Medical Research Foundation, 13th St., Oklahoma City, Okla. 73104.",

year = "1982",

month = may,

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doi = "10.1016/0008-8749(82)90069-7",

language = "English (US)",

volume = "69",

pages = "227--234",

journal = "Cellular Immunology",

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publisher = "Academic Press Inc.",

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T1 - Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice

AU - Wustrow, T. P.U.

AU - Denny, T. N.

AU - Fernandes, G.

AU - Good, R. A.

N1 - Funding Information: ’ Aided by grants from the Department of Health and Human Services, AG 00541, AG 02247, AI 11843, NS 11457, the Zelda Radow Weintraub Cancer Fund, the Richard Molin Foundation, and the Joe Brooks Fund. * Supported by the Deutsch Forschungsgmeinschaft Grant WU 111 /I. 3 To whom all correspondence should be sent at: Oklahoma Medical Research Foundation, 13th St., Oklahoma City, Okla. 73104.

PY - 1982/5/15

Y1 - 1982/5/15

N2 - Changes in phagocytosis, chemotaxis, and nonspecific esterase staining of peritoneal exudate mononuclear cells occurred with aging in B6, AKR/J, and SJL/J mice. Different patterns of change with aging were observed with each of these three parameters in each of the strains. In the long-lived B6 mice, a progressive increase with aging in all three parameters was seen. In AKR/J mice, progressive increase in phagocytosis and nonspecific esterase staining was observed but a decline of chemotaxis occurred with aging. In SJL/J mice, all three parameters were very low early in life and each showed a significant increment upon reaching the age when the characteristic malignant lymphoreticular disease occurs.

AB - Changes in phagocytosis, chemotaxis, and nonspecific esterase staining of peritoneal exudate mononuclear cells occurred with aging in B6, AKR/J, and SJL/J mice. Different patterns of change with aging were observed with each of these three parameters in each of the strains. In the long-lived B6 mice, a progressive increase with aging in all three parameters was seen. In AKR/J mice, progressive increase in phagocytosis and nonspecific esterase staining was observed but a decline of chemotaxis occurred with aging. In SJL/J mice, all three parameters were very low early in life and each showed a significant increment upon reaching the age when the characteristic malignant lymphoreticular disease occurs.

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Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice

Abstract

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