Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice

T. P.U. Wustrow, T. N. Denny, G. Fernandes, R. A. Good

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Changes in phagocytosis, chemotaxis, and nonspecific esterase staining of peritoneal exudate mononuclear cells occurred with aging in B6, AKR/J, and SJL/J mice. Different patterns of change with aging were observed with each of these three parameters in each of the strains. In the long-lived B6 mice, a progressive increase with aging in all three parameters was seen. In AKR/J mice, progressive increase in phagocytosis and nonspecific esterase staining was observed but a decline of chemotaxis occurred with aging. In SJL/J mice, all three parameters were very low early in life and each showed a significant increment upon reaching the age when the characteristic malignant lymphoreticular disease occurs.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalCellular Immunology
Volume69
Issue number2
DOIs
StatePublished - May 15 1982

ASJC Scopus subject areas

  • Immunology

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