Abstract
Acute i.p. administration of morphine or cocaine produced increase in locomotor activity in Swiss-Webster female mice that were maximal at 32-100 mg/kg for morphine and at 32 mg/kg for cocaine. WIN 35,197-2 produced dose-dependent decreases in locomotor activity from 3.2-32 mg/kg. Chronic administration of WIN 35,197-2 led to a 6-10 fold shift to the right in the locomotor activity decreasing effect of the drug, but WIN 35,197-2-tolerant mice retained their sensitivity to the locomotor stimulant effects of morphine and cocaine. Acute administration of WIN 35,197-2 failed to sensitize mice to naloxone-induced jumping, although morphine did so. Chronic administration of WIN 35,197-2 did lead to sensitization to naloxone, but WIN 35,197-2 was much less efficacious in this regard than morphine. These behavioral effects of WIN 35,197-2 may be helpful in the classification of modes of action of different narcotic agonists.
Original language | English (US) |
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Pages (from-to) | 125-129 |
Number of pages | 5 |
Journal | Psychopharmacology |
Volume | 58 |
Issue number | 2 |
DOIs | |
State | Published - Jan 1978 |
Externally published | Yes |
Keywords
- Cocaine
- Locomotor activity
- Mice
- Morphine
- Naloxone-induced jumping
- WIN 35,197-2
ASJC Scopus subject areas
- Pharmacology