Changes in lipid composition of cortical synaptosomes from different age groups of mice

W. G. Wood, R. Strong, L. S. Williamson, R. W. Wise

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Lipid composition of cortical synaptosomes differed with age in C57BL/6NNIA mice. Significant age differences were observed for cholesterol and the ratio of cholesterol to total phospholipid phosphorus content. The phospholipid to protein ratio of individual phospholipids also increased with age with diacyl-sn-glycero-3-phosphocholine (PC) increasing the most. Acyl group composition of individual phospholipids, however, showed little age difference. The double bond index for PC decreased significantly with age. Changes in membrane composition may help explain differences in the effects of ethanol on the physical and biochemical properties of membranes from different age groups that have been reported previously.

Original languageEnglish (US)
Pages (from-to)1947-1952
Number of pages6
JournalLife Sciences
Volume35
Issue number19
DOIs
StatePublished - Nov 5 1984
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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