Changes in brain protein synthesis during the life span of male Fischer rats

R. Ekstrom, D. S H Liu, A. Richardson

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The cell-free protein synthetic activity of the postmitochondrial supernatant isolated from whole brain of 6 to 32 mth old male Fischer F344 rats was compared. Protein synthesis decreased 56% from 6 to 32 mth of age. The decrease in cell-free protein synthesis was not due to an age-related increase in RNase activity. Although monomeric ribosomes (ribosomes stripped of mRNA) isolated from the brains of older rats were less active in polyuridylic acid directed polyphenylalanine synthesis, the fidelity of polyuridylic acid translation by monomeric ribosomes did not decrease with increasing age.

Original languageEnglish (US)
Pages (from-to)121-128
Number of pages8
JournalGerontology
Volume26
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Inbred F344 Rats
Ribosomes
Poly U
Brain
Proteins
Ribonucleases
Messenger RNA

ASJC Scopus subject areas

  • Aging

Cite this

Ekstrom, R., Liu, D. S. H., & Richardson, A. (1980). Changes in brain protein synthesis during the life span of male Fischer rats. Gerontology, 26(3), 121-128.

Changes in brain protein synthesis during the life span of male Fischer rats. / Ekstrom, R.; Liu, D. S H; Richardson, A.

In: Gerontology, Vol. 26, No. 3, 1980, p. 121-128.

Research output: Contribution to journalArticle

Ekstrom, R, Liu, DSH & Richardson, A 1980, 'Changes in brain protein synthesis during the life span of male Fischer rats', Gerontology, vol. 26, no. 3, pp. 121-128.
Ekstrom, R. ; Liu, D. S H ; Richardson, A. / Changes in brain protein synthesis during the life span of male Fischer rats. In: Gerontology. 1980 ; Vol. 26, No. 3. pp. 121-128.
@article{9d8c970b1284493b85e2e90189d51122,
title = "Changes in brain protein synthesis during the life span of male Fischer rats",
abstract = "The cell-free protein synthetic activity of the postmitochondrial supernatant isolated from whole brain of 6 to 32 mth old male Fischer F344 rats was compared. Protein synthesis decreased 56{\%} from 6 to 32 mth of age. The decrease in cell-free protein synthesis was not due to an age-related increase in RNase activity. Although monomeric ribosomes (ribosomes stripped of mRNA) isolated from the brains of older rats were less active in polyuridylic acid directed polyphenylalanine synthesis, the fidelity of polyuridylic acid translation by monomeric ribosomes did not decrease with increasing age.",
author = "R. Ekstrom and Liu, {D. S H} and A. Richardson",
year = "1980",
language = "English (US)",
volume = "26",
pages = "121--128",
journal = "Gerontology",
issn = "0304-324X",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Changes in brain protein synthesis during the life span of male Fischer rats

AU - Ekstrom, R.

AU - Liu, D. S H

AU - Richardson, A.

PY - 1980

Y1 - 1980

N2 - The cell-free protein synthetic activity of the postmitochondrial supernatant isolated from whole brain of 6 to 32 mth old male Fischer F344 rats was compared. Protein synthesis decreased 56% from 6 to 32 mth of age. The decrease in cell-free protein synthesis was not due to an age-related increase in RNase activity. Although monomeric ribosomes (ribosomes stripped of mRNA) isolated from the brains of older rats were less active in polyuridylic acid directed polyphenylalanine synthesis, the fidelity of polyuridylic acid translation by monomeric ribosomes did not decrease with increasing age.

AB - The cell-free protein synthetic activity of the postmitochondrial supernatant isolated from whole brain of 6 to 32 mth old male Fischer F344 rats was compared. Protein synthesis decreased 56% from 6 to 32 mth of age. The decrease in cell-free protein synthesis was not due to an age-related increase in RNase activity. Although monomeric ribosomes (ribosomes stripped of mRNA) isolated from the brains of older rats were less active in polyuridylic acid directed polyphenylalanine synthesis, the fidelity of polyuridylic acid translation by monomeric ribosomes did not decrease with increasing age.

UR - http://www.scopus.com/inward/record.url?scp=0018907195&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018907195&partnerID=8YFLogxK

M3 - Article

C2 - 7358282

AN - SCOPUS:0018907195

VL - 26

SP - 121

EP - 128

JO - Gerontology

JF - Gerontology

SN - 0304-324X

IS - 3

ER -