Challenges of conducting multi-center, multi-disciplinary urinary incontinence clinical trials: Experience of the Urinary Incontinence Treatment Network

William Steers, Holly Richter, Leroy Nyberg, John Kusek, Stephen Kraus, Kimberly Dandreo, Toby Chai, Linda Brubaker

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Aims: The Urinary Incontinence Treatment Network (UITN) was established in 2000 as a multi-disciplinary, multi-institutional network by the National Institute for Diabetes, Digestive, and Kidney Diseases (NIDDK) to investigate treatments for urinary incontinence in women. Methods: Over 8 years this network composed of urologists, urogynecologists, geriatricians, behavioral psychologists, physical therapists, nurses, epidemiologists, social scientists and statisticians from nine academic sites and a Data Coordinating Center has been effective in designing and completing prospective randomized clinical trials for treatments of urinary incontinence in women. Results: Two major clinical trials have been completed and a third has completed recruitment. The focus of the completed trials was a comparison of surgical methods to treat stress urinary incontinence whereas the third examined the potential benefit of combined behavioral intervention and antimuscarinic drug therapy to eliminate the need for long-term use of drug therapy alone to manage urge urinary incontinence. The scientific output of the network measured by abstracts, original papers and presentations demonstrates the productivity of the network. Conclusions: Many unique challenges are posed by a multi-disciplinary team located at sites across the United States undertaking several clinical trials. This review presents some of the logistics, barriers, tactics, and strategies used to create this successful clinical trials network focused on urinary incontinence.

Original languageEnglish (US)
Pages (from-to)170-176
Number of pages7
JournalNeurourology and Urodynamics
Volume28
Issue number3
DOIs
StatePublished - 2009

Keywords

  • Behavioral therapy
  • Clinical trials
  • Colposuspension
  • Slings
  • Urinary Incontinence Treatment Network
  • Urinary incontinence

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology

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