Challenges in developing Geroscience trials

Yves Rolland, Felipe Sierra, Luigi Ferrucci, Nir Barzilai, Rafael De Cabo, Joan Mannick, Anthony Oliva, William Evans, Davide Angioni, Philipe De Souto Barreto, Jeremy Raffin, Bruno Vellas, James L. Kirkland, Sandrine Andrieu, Daniel Bacqueville, Heike Bischoff-Ferrari, Guillaume Blivet, Timothy Cash, Ana Maria Cuervo, Noelie DavezacAndrea Dimet-Wiley, Alexander Fleming, Friedlander Gérard, Mitzi Gonzales, Sophie Guyonnet, Joshua Hare, Suzanne Hendrix, Christian Jorgensen, Matt Kaeberlein, Mehmood Khan, Stephen Kritchevsky, Aksana Labokha, Olivier Lairez, Stephanie Lederman, Jean Mariani, Lefkos Middleton, John Newman, Angelo Parini, Susan Peschin, Marco Prunotto, Sami Sagol, Suzanne Tomlinson, Georg Terstappen, Jacques Touchon, Cendrine Tourette, Rob Van Maanen, Eric Verdin, Stan Watowich, Lei Zhang, Alex Zhavoronkov

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Geroscience is becoming a major hope for preventing age-related diseases and loss of function by targeting biological mechanisms of aging. This unprecedented paradigm shift requires optimizing the design of future clinical studies related to aging in humans. Researchers will face a number of challenges, including ideal populations to study, which lifestyle and Gerotherapeutic interventions to test initially, selecting key primary and secondary outcomes of such clinical trials, and which age-related biomarkers are most valuable for both selecting interventions and predicting or monitoring clinical responses (“Gerodiagnostics”). This article reports the main results of a Task Force of experts in Geroscience.

Original languageEnglish (US)
Article number5038
JournalNature communications
Issue number1
StatePublished - Dec 2023

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry, Genetics and Molecular Biology
  • General Physics and Astronomy


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