Chagas heart disease: A contemporary review

Alejandro Velasco, Carlos A. Morillo

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Chagas disease is caused by a parasite infection endemic of the Americas. Traditionally observed in rural areas of Latin America, current migration trends have turned Chagas disease into a global epidemic. Acute infection is rarely severe and once it resolves, some patients can develop cardiomyopathy as part of the chronic form many years later. Multiple factors related with both the host and the parasite determine the susceptibility and progression to cardiomyopathy. Current imaging techniques are able to identify cardiac autonomic denervation, perfusion abnormalities, and myocardial fibrosis at an early of stage before the development of symptoms. The prognosis of patients with Chagasic cardiomyopathy remains poor and life-threatening ventricular arrhythmias can occur at an early stage. Treatment of chronic Chagas cardiomyopathy is challenging with a great need for more studies in the field.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalJournal of Nuclear Cardiology
Issue number2
StatePublished - Apr 1 2020
Externally publishedYes


  • Cardiac innervation
  • Cardiomyopathy
  • Infection
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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