TY - JOUR
T1 - Cervicitis and genitourinary symptoms in women culture positive for Mycoplasma genitalium
AU - Korte, Jeffrey E.
AU - Baseman, Joel B.
AU - Cagle, Marianna P.
AU - Herrera, Caleb
AU - Piper, Jeanna M.
AU - Holden, Alan E.C.
AU - Perdue, Sondra T.
AU - Champion, Jane D.
AU - Shain, Rochelle N.
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Problem: Mycoplasma genitalium has been associated with male urethritis. We sought to relate M. genitalium to genitourinary signs and symptoms in women. Method of study: We compared 26 culture-positive women (group 1), 257 additional polymerase chain reaction-positive women (group 2), and 107 negative control women. We used logistic regression to evaluate signs and symptoms, controlling for co-infections, pregnancy, age, and intervention group assignment. Results: Comparing group 1 with controls, we found significantly elevated odds ratios (ORs) for intermediate vaginal discharge (OR = 5.4; 95% confidence interval 1.01, 29.2) and action in response to discharge [3.9 (1.1, 13.5)]. Non-significant increases were observed for pathologic vaginal discharge [3.8 (0.78, 18.2)], pathologic dyspareunia [1.5 (0.25, 9.0)], vaginal odor [2.1 (0.75, 5.7)], and cervical mucopus [4.1 (0.74, 22.4)]. Group 2 results were similar, but showed no increase in cervical mucopus relative to controls. Conclusion: Infection with M. genitalium in women is independently related to increased genitourinary symptomatology.
AB - Problem: Mycoplasma genitalium has been associated with male urethritis. We sought to relate M. genitalium to genitourinary signs and symptoms in women. Method of study: We compared 26 culture-positive women (group 1), 257 additional polymerase chain reaction-positive women (group 2), and 107 negative control women. We used logistic regression to evaluate signs and symptoms, controlling for co-infections, pregnancy, age, and intervention group assignment. Results: Comparing group 1 with controls, we found significantly elevated odds ratios (ORs) for intermediate vaginal discharge (OR = 5.4; 95% confidence interval 1.01, 29.2) and action in response to discharge [3.9 (1.1, 13.5)]. Non-significant increases were observed for pathologic vaginal discharge [3.8 (0.78, 18.2)], pathologic dyspareunia [1.5 (0.25, 9.0)], vaginal odor [2.1 (0.75, 5.7)], and cervical mucopus [4.1 (0.74, 22.4)]. Group 2 results were similar, but showed no increase in cervical mucopus relative to controls. Conclusion: Infection with M. genitalium in women is independently related to increased genitourinary symptomatology.
KW - Cervicitis
KW - Mycoplasma genitalium
KW - Sexually transmitted diseases
KW - Signs and symptoms
KW - Vaginal discharge
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U2 - 10.1111/j.1600-0897.2005.00359.x
DO - 10.1111/j.1600-0897.2005.00359.x
M3 - Article
C2 - 16533338
AN - SCOPUS:33644814952
VL - 55
SP - 265
EP - 275
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
SN - 8755-8920
IS - 4
ER -