Cervicitis and genitourinary symptoms in women culture positive for Mycoplasma genitalium

Jeffrey E. Korte, Joel B. Baseman, Marianna P. Cagle, Caleb Herrera, Jeanna M. Piper, Alan E.C. Holden, Sondra T. Perdue, Jane D. Champion, Rochelle N. Shain

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Problem: Mycoplasma genitalium has been associated with male urethritis. We sought to relate M. genitalium to genitourinary signs and symptoms in women. Method of study: We compared 26 culture-positive women (group 1), 257 additional polymerase chain reaction-positive women (group 2), and 107 negative control women. We used logistic regression to evaluate signs and symptoms, controlling for co-infections, pregnancy, age, and intervention group assignment. Results: Comparing group 1 with controls, we found significantly elevated odds ratios (ORs) for intermediate vaginal discharge (OR = 5.4; 95% confidence interval 1.01, 29.2) and action in response to discharge [3.9 (1.1, 13.5)]. Non-significant increases were observed for pathologic vaginal discharge [3.8 (0.78, 18.2)], pathologic dyspareunia [1.5 (0.25, 9.0)], vaginal odor [2.1 (0.75, 5.7)], and cervical mucopus [4.1 (0.74, 22.4)]. Group 2 results were similar, but showed no increase in cervical mucopus relative to controls. Conclusion: Infection with M. genitalium in women is independently related to increased genitourinary symptomatology.

Original languageEnglish (US)
Pages (from-to)265-275
Number of pages11
JournalAmerican Journal of Reproductive Immunology
Issue number4
StatePublished - Apr 2006


  • Cervicitis
  • Mycoplasma genitalium
  • Sexually transmitted diseases
  • Signs and symptoms
  • Vaginal discharge

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology


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