Cervical adenocarcinoma in Situ: A systematic review of therapeutic options and predictors of persistent or recurrent disease

Thomas C. Krivak, G. Scott Rose, John W. McBroom, Jay W. Carlson, William E. Winter, Edward R Kost

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The incidence of cervical adenocarcinoma in situ is increasing in frequency, and our limited knowledge about this lesion presents the physician with a therapeutic dilemma. Treatment for this lesion has included conservative therapy, large loop excision or cold-knife cone biopsy, or definitive therapy consisting of hysterectomy. But, rates of residual adenocarcinoma in situ after cone biopsy with negative margins vary from 0% to 40%, and residual disease rates as high as 80% have been noted when the margins are positive. Despite these recent data on follow-up after conservative therapy such as cone biopsy, it seems that this method is safe and gaining acceptance by many physicians and patients. However, the short follow-up duration and small number of patients limit the conclusions of many studies. The relative infrequency of this diagnosis has precluded extensive clinical experience with the natural history of this lesion.

Original languageEnglish (US)
Pages (from-to)567-575
Number of pages9
JournalObstetrical and Gynecological Survey
Volume56
Issue number9
DOIs
StatePublished - 2001
Externally publishedYes

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Biopsy
Physicians
Natural History
Hysterectomy
Therapeutics
Incidence
Adenocarcinoma in Situ
Conservative Treatment

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Cervical adenocarcinoma in Situ : A systematic review of therapeutic options and predictors of persistent or recurrent disease. / Krivak, Thomas C.; Rose, G. Scott; McBroom, John W.; Carlson, Jay W.; Winter, William E.; Kost, Edward R.

In: Obstetrical and Gynecological Survey, Vol. 56, No. 9, 2001, p. 567-575.

Research output: Contribution to journalArticle

Krivak, Thomas C. ; Rose, G. Scott ; McBroom, John W. ; Carlson, Jay W. ; Winter, William E. ; Kost, Edward R. / Cervical adenocarcinoma in Situ : A systematic review of therapeutic options and predictors of persistent or recurrent disease. In: Obstetrical and Gynecological Survey. 2001 ; Vol. 56, No. 9. pp. 567-575.
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