Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia

Xianlin Han, Anne M. Fagan, Hua Cheng, John C. Morris, Chengjie Xiong, David M. Holtzman

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


We recently noted a profound decline in brain sulfatides (ST) in subjects who died with incipient dementia due to Alzheimer's disease. Herein, we measured ST levels in cerebrospinal fluid in cognitively normal elderly and in subjects with mild cognitive impairment due to incipient demenia of the Alzheimer type. There was a significant decrease in cerebrospinal fluid ST and in the ST to phosphatidylinositol ratio in MCI subjects. The ST to phosphatidylinositol ratio accurately differentiated very mildly impaired subjects from controls on an individual basis. The cerebrospinal fluid ST to phosphatidylinositol ratio may be a very useful biomarker for the earliest clinical stage of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalAnnals of neurology
Issue number1
StatePublished - Jul 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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