Cerebrospinal Fluid Levels of Endotoxin During Endotoxemia

Nick C. Trippodo; James H. Jorgensen; Lawrence L. Priano; Daniel L. Traber

doi:10.3181/00379727-143-37444

Cerebrospinal Fluid Levels of Endotoxin During Endotoxemia

Nick C. Trippodo, James H. Jorgensen, Lawrence L. Priano, Daniel L. Traber

Pathology

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

Dogs were given E. coli endotoxin intravenously to produce the typical hemodynamic and respiratory shock state. Plasma and cerebrospinal fluid levels of endotoxin were measured by the Limulus in vitro endotoxin assay at predetermined intervals for two hours. During the period when the plasma concentration was at its highest, no endotoxin was detected in the cerebrospinal fluid. These results suggest that systemic endotoxin does not produce its effects by acting directly on the central nervous system during the early phase of endotoxemia.

Original language	English (US)
Pages (from-to)	932-937
Number of pages	6
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	143
Issue number	4
DOIs	https://doi.org/10.3181/00379727-143-37444
State	Published - Sep 1973

Fingerprint

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Trippodo, N. C., Jorgensen, J. H., Priano, L. L., & Traber, D. L. (1973). Cerebrospinal Fluid Levels of Endotoxin During Endotoxemia. Proceedings of the Society for Experimental Biology and Medicine, 143(4), 932-937. https://doi.org/10.3181/00379727-143-37444

@article{c3618ed63e4747ea837e938a6c6461be,

title = "Cerebrospinal Fluid Levels of Endotoxin During Endotoxemia",

abstract = "Dogs were given E. coli endotoxin intravenously to produce the typical hemodynamic and respiratory shock state. Plasma and cerebrospinal fluid levels of endotoxin were measured by the Limulus in vitro endotoxin assay at predetermined intervals for two hours. During the period when the plasma concentration was at its highest, no endotoxin was detected in the cerebrospinal fluid. These results suggest that systemic endotoxin does not produce its effects by acting directly on the central nervous system during the early phase of endotoxemia.",

author = "Trippodo, {Nick C.} and Jorgensen, {James H.} and Priano, {Lawrence L.} and Traber, {Daniel L.}",

year = "1973",

month = sep,

doi = "10.3181/00379727-143-37444",

language = "English (US)",

volume = "143",

pages = "932--937",

journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",

issn = "1535-3702",

publisher = "Society for Experimental Biology and Medicine",

number = "4",

}

TY - JOUR

T1 - Cerebrospinal Fluid Levels of Endotoxin During Endotoxemia

AU - Trippodo, Nick C.

AU - Jorgensen, James H.

AU - Priano, Lawrence L.

AU - Traber, Daniel L.

PY - 1973/9

Y1 - 1973/9

N2 - Dogs were given E. coli endotoxin intravenously to produce the typical hemodynamic and respiratory shock state. Plasma and cerebrospinal fluid levels of endotoxin were measured by the Limulus in vitro endotoxin assay at predetermined intervals for two hours. During the period when the plasma concentration was at its highest, no endotoxin was detected in the cerebrospinal fluid. These results suggest that systemic endotoxin does not produce its effects by acting directly on the central nervous system during the early phase of endotoxemia.

AB - Dogs were given E. coli endotoxin intravenously to produce the typical hemodynamic and respiratory shock state. Plasma and cerebrospinal fluid levels of endotoxin were measured by the Limulus in vitro endotoxin assay at predetermined intervals for two hours. During the period when the plasma concentration was at its highest, no endotoxin was detected in the cerebrospinal fluid. These results suggest that systemic endotoxin does not produce its effects by acting directly on the central nervous system during the early phase of endotoxemia.

UR - http://www.scopus.com/inward/record.url?scp=0015819290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015819290&partnerID=8YFLogxK

U2 - 10.3181/00379727-143-37444

DO - 10.3181/00379727-143-37444

M3 - Article

C2 - 4582774

AN - SCOPUS:0015819290

VL - 143

SP - 932

EP - 937

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

SN - 1535-3702

IS - 4

ER -

Access to Document

10.3181/00379727-143-37444