Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease

Natalia P. Rocha; Andre Toledo; Laiane T.S. Corgosinho; Leonardo C. de Souza; Henrique C. Guimarães; Elisa P.F. Resende; Nayara F.T. Braz; Karina B. Gomes; Ana C. Simoes E Silva; Paulo Caramelli; Antonio L. Teixeira

doi:10.3233/JAD-180282

Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease

Natalia P. Rocha
, Andre Toledo
, Laiane T.S. Corgosinho
, Leonardo C. de Souza
, Henrique C. Guimarães
, Elisa P.F. Resende
, Nayara F.T. Braz
, Karina B. Gomes
, Ana C. Simoes E Silva
, Paulo Caramelli
, Antonio L. Teixeira

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

This study was designed to determine whether the levels of renin-angiotensin system (RAS) components are associated with Alzheimer's disease (AD) pathology. Cerebrospinal fluid levels of Angiotensin (Ang) II, Ang-(1-7), angiotensin-converting enzyme (ACE), ACE2, Amyloid-β (Aβ)40, Aβ42, total tau (hTau), and phospho-tau (pTau) were measured in 18 patients with AD and 10 controls. Patients with AD presented decreased levels of ACE when compared with controls. We found a significant positive correlation between ACE and Aβ42 levels among patients. Our results strengthen the hypothesis that ACE is associated with Aβ pathology in AD.

Original language	English (US)
Pages (from-to)	1085-1090
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	64
Issue number	4
DOIs	https://doi.org/10.3233/JAD-180282
State	Published - 2018
Externally published	Yes

Keywords

Alzheimer’s disease
amyloid-beta
angiotensin-converting enzyme
biomarkers
renin-angiotensin system

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-180282

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Rocha, N. P., Toledo, A., Corgosinho, L. T. S., de Souza, L. C., Guimarães, H. C., Resende, E. P. F., Braz, N. F. T., Gomes, K. B., Simoes E Silva, A. C., Caramelli, P., & Teixeira, A. L. (2018). Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease. Journal of Alzheimer's Disease, 64(4), 1085-1090. https://doi.org/10.3233/JAD-180282

Rocha, NP, Toledo, A, Corgosinho, LTS, de Souza, LC, Guimarães, HC, Resende, EPF, Braz, NFT, Gomes, KB, Simoes E Silva, AC, Caramelli, P & Teixeira, AL 2018, 'Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease', Journal of Alzheimer's Disease, vol. 64, no. 4, pp. 1085-1090. https://doi.org/10.3233/JAD-180282

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title = "Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease",

abstract = "This study was designed to determine whether the levels of renin-angiotensin system (RAS) components are associated with Alzheimer's disease (AD) pathology. Cerebrospinal fluid levels of Angiotensin (Ang) II, Ang-(1-7), angiotensin-converting enzyme (ACE), ACE2, Amyloid-β (Aβ)40, Aβ42, total tau (hTau), and phospho-tau (pTau) were measured in 18 patients with AD and 10 controls. Patients with AD presented decreased levels of ACE when compared with controls. We found a significant positive correlation between ACE and Aβ42 levels among patients. Our results strengthen the hypothesis that ACE is associated with Aβ pathology in AD.",

keywords = "Alzheimer{\textquoteright}s disease, amyloid-beta, angiotensin-converting enzyme, biomarkers, renin-angiotensin system",

author = "Rocha, \{Natalia P.\} and Andre Toledo and Corgosinho, \{Laiane T.S.\} and \{de Souza\}, \{Leonardo C.\} and Guimar{\~a}es, \{Henrique C.\} and Resende, \{Elisa P.F.\} and Braz, \{Nayara F.T.\} and Gomes, \{Karina B.\} and \{Simoes E Silva\}, \{Ana C.\} and Paulo Caramelli and Teixeira, \{Antonio L.\}",

year = "2018",

doi = "10.3233/JAD-180282",

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AU - de Souza, Leonardo C.

AU - Guimarães, Henrique C.

AU - Resende, Elisa P.F.

AU - Braz, Nayara F.T.

AU - Gomes, Karina B.

AU - Simoes E Silva, Ana C.

AU - Caramelli, Paulo

AU - Teixeira, Antonio L.

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AB - This study was designed to determine whether the levels of renin-angiotensin system (RAS) components are associated with Alzheimer's disease (AD) pathology. Cerebrospinal fluid levels of Angiotensin (Ang) II, Ang-(1-7), angiotensin-converting enzyme (ACE), ACE2, Amyloid-β (Aβ)40, Aβ42, total tau (hTau), and phospho-tau (pTau) were measured in 18 patients with AD and 10 controls. Patients with AD presented decreased levels of ACE when compared with controls. We found a significant positive correlation between ACE and Aβ42 levels among patients. Our results strengthen the hypothesis that ACE is associated with Aβ pathology in AD.

KW - Alzheimer’s disease

KW - amyloid-beta

KW - angiotensin-converting enzyme

KW - biomarkers

KW - renin-angiotensin system

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Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease

Abstract

Keywords

ASJC Scopus subject areas

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