Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease

Natalia P. Rocha; Andre Toledo; Laiane T.S. Corgosinho; Leonardo C. de Souza; Henrique C. Guimarães; Elisa P.F. Resende; Nayara F.T. Braz; Karina B. Gomes; Ana C. Simoes E Silva; Paulo Caramelli; Antonio L. Teixeira

doi:10.3233/JAD-180282

Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease

Natalia P. Rocha, Andre Toledo, Laiane T.S. Corgosinho, Leonardo C. de Souza, Henrique C. Guimarães, Elisa P.F. Resende, Nayara F.T. Braz, Karina B. Gomes, Ana C. Simoes E Silva, Paulo Caramelli, Antonio L. Teixeira

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

This study was designed to determine whether the levels of renin-angiotensin system (RAS) components are associated with Alzheimer's disease (AD) pathology. Cerebrospinal fluid levels of Angiotensin (Ang) II, Ang-(1-7), angiotensin-converting enzyme (ACE), ACE2, Amyloid-β (Aβ)40, Aβ42, total tau (hTau), and phospho-tau (pTau) were measured in 18 patients with AD and 10 controls. Patients with AD presented decreased levels of ACE when compared with controls. We found a significant positive correlation between ACE and Aβ42 levels among patients. Our results strengthen the hypothesis that ACE is associated with Aβ pathology in AD.

Original language	English (US)
Pages (from-to)	1085-1090
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	64
Issue number	4
DOIs	https://doi.org/10.3233/JAD-180282
State	Published - 2018
Externally published	Yes

Keywords

Alzheimer’s disease
amyloid-beta
angiotensin-converting enzyme
biomarkers
renin-angiotensin system

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-180282

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Rocha, N. P., Toledo, A., Corgosinho, L. T. S., de Souza, L. C., Guimarães, H. C., Resende, E. P. F., Braz, N. F. T., Gomes, K. B., Simoes E Silva, A. C., Caramelli, P., & Teixeira, A. L. (2018). Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease. Journal of Alzheimer's Disease, 64(4), 1085-1090. https://doi.org/10.3233/JAD-180282

Rocha, NP, Toledo, A, Corgosinho, LTS, de Souza, LC, Guimarães, HC, Resende, EPF, Braz, NFT, Gomes, KB, Simoes E Silva, AC, Caramelli, P & Teixeira, AL 2018, 'Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease', Journal of Alzheimer's Disease, vol. 64, no. 4, pp. 1085-1090. https://doi.org/10.3233/JAD-180282

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title = "Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease",

abstract = "This study was designed to determine whether the levels of renin-angiotensin system (RAS) components are associated with Alzheimer's disease (AD) pathology. Cerebrospinal fluid levels of Angiotensin (Ang) II, Ang-(1-7), angiotensin-converting enzyme (ACE), ACE2, Amyloid-β (Aβ)40, Aβ42, total tau (hTau), and phospho-tau (pTau) were measured in 18 patients with AD and 10 controls. Patients with AD presented decreased levels of ACE when compared with controls. We found a significant positive correlation between ACE and Aβ42 levels among patients. Our results strengthen the hypothesis that ACE is associated with Aβ pathology in AD.",

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author = "Rocha, {Natalia P.} and Andre Toledo and Corgosinho, {Laiane T.S.} and {de Souza}, {Leonardo C.} and Guimar{\~a}es, {Henrique C.} and Resende, {Elisa P.F.} and Braz, {Nayara F.T.} and Gomes, {Karina B.} and {Simoes E Silva}, {Ana C.} and Paulo Caramelli and Teixeira, {Antonio L.}",

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doi = "10.3233/JAD-180282",

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AU - de Souza, Leonardo C.

AU - Guimarães, Henrique C.

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AU - Simoes E Silva, Ana C.

AU - Caramelli, Paulo

AU - Teixeira, Antonio L.

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KW - angiotensin-converting enzyme

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Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer's Disease

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Keywords

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