Cerebrospinal fluid HVA, central brain atrophy, and clinical state in schizophrenia

John P. Houston; James W. Maas; Charles L. Bowden; Salvador A. Contreras; Kathryn L. McIntyre; Martin A. Javors

doi:10.1016/0165-1781(86)90099-5

Cerebrospinal fluid HVA, central brain atrophy, and clinical state in schizophrenia

John P. Houston, James W. Maas, Charles L. Bowden, Salvador A. Contreras, Kathryn L. McIntyre, Martin A. Javors

Department of Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

In 16 patients with chronic schizophrenia, cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) showed a significant negative correlation with computed tomographic measures of brain third ventricle size. Clinical state during a drug-free period was also significantly correlated with CSF HVA level, but not with third ventricle size when the effect of CSF HVA was partialed out. The authors propose that these findings may reflect an atrophic process involving structures around the third ventricle and a decrease in dopaminergic activity.

Original language	English (US)
Pages (from-to)	207-214
Number of pages	8
Journal	Psychiatry Research
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(86)90099-5
State	Published - Nov 1986

Keywords

Schizophrenia
brain atrophy
computed tomography
homovanillic acid

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(86)90099-5

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title = "Cerebrospinal fluid HVA, central brain atrophy, and clinical state in schizophrenia",

abstract = "In 16 patients with chronic schizophrenia, cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) showed a significant negative correlation with computed tomographic measures of brain third ventricle size. Clinical state during a drug-free period was also significantly correlated with CSF HVA level, but not with third ventricle size when the effect of CSF HVA was partialed out. The authors propose that these findings may reflect an atrophic process involving structures around the third ventricle and a decrease in dopaminergic activity.",

keywords = "Schizophrenia, brain atrophy, computed tomography, homovanillic acid",

author = "Houston, {John P.} and Maas, {James W.} and Bowden, {Charles L.} and Contreras, {Salvador A.} and McIntyre, {Kathryn L.} and Javors, {Martin A.}",

note = "Funding Information: Acknowledgments. This work was supported by VA Medical Research Funds, Mary Yates Memorial Fund through The Hogg Foundation for Mental Health, The University of Texas, and NIM H Grant No. M H-40935-0I . We thank the staff of Unit I-C and the Radiology Service of the Audie L. Murphy Memorial Veterans Hospital for their active participation and assistancei n this research; and C.D. Taylor for technical assistancei n HVA assays.",

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AU - Houston, John P.

AU - Maas, James W.

AU - Bowden, Charles L.

AU - Contreras, Salvador A.

AU - McIntyre, Kathryn L.

AU - Javors, Martin A.

N1 - Funding Information: Acknowledgments. This work was supported by VA Medical Research Funds, Mary Yates Memorial Fund through The Hogg Foundation for Mental Health, The University of Texas, and NIM H Grant No. M H-40935-0I . We thank the staff of Unit I-C and the Radiology Service of the Audie L. Murphy Memorial Veterans Hospital for their active participation and assistancei n this research; and C.D. Taylor for technical assistancei n HVA assays.

PY - 1986/11

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N2 - In 16 patients with chronic schizophrenia, cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) showed a significant negative correlation with computed tomographic measures of brain third ventricle size. Clinical state during a drug-free period was also significantly correlated with CSF HVA level, but not with third ventricle size when the effect of CSF HVA was partialed out. The authors propose that these findings may reflect an atrophic process involving structures around the third ventricle and a decrease in dopaminergic activity.

AB - In 16 patients with chronic schizophrenia, cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) showed a significant negative correlation with computed tomographic measures of brain third ventricle size. Clinical state during a drug-free period was also significantly correlated with CSF HVA level, but not with third ventricle size when the effect of CSF HVA was partialed out. The authors propose that these findings may reflect an atrophic process involving structures around the third ventricle and a decrease in dopaminergic activity.

KW - Schizophrenia

KW - brain atrophy

KW - computed tomography

KW - homovanillic acid

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Cerebrospinal fluid HVA, central brain atrophy, and clinical state in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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