Cerebrospinal fluid HVA, central brain atrophy, and clinical state in schizophrenia

John P. Houston, James W. Maas, Charles L. Bowden, Salvador A. Contreras, Kathryn L. McIntyre, Martin A. Javors

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


In 16 patients with chronic schizophrenia, cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) showed a significant negative correlation with computed tomographic measures of brain third ventricle size. Clinical state during a drug-free period was also significantly correlated with CSF HVA level, but not with third ventricle size when the effect of CSF HVA was partialed out. The authors propose that these findings may reflect an atrophic process involving structures around the third ventricle and a decrease in dopaminergic activity.

Original languageEnglish (US)
Pages (from-to)207-214
Number of pages8
JournalPsychiatry Research
Issue number3
StatePublished - Nov 1986


  • Schizophrenia
  • brain atrophy
  • computed tomography
  • homovanillic acid

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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