Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis

I. Jon Russell, Henning Vaeroy, Martin Javors, Fred Nyberg

Research output: Contribution to journalArticle

419 Scopus citations

Abstract

Objective. To compare the levels of biogenic amines in the cerebrospinal fluid (CSF) of primary fibromyalgia syndrome (PFS) patients with those in the CSF of controls. Methods. Metabolites of serotonin, norepinephrine, and dopamine were identified in CSF, using high performance liquid chromatography with coulometric detection. Results. CSF levels of metabolites from all 3 neurotransmitters were lower in PFS patients than in controls. Conclusion. A low rate of turnover of several neurotransmitters supports the proposed hypothesis of a metabolic defect in PFS and suggests that the defect occurs at a neuroregulatory level.

Original languageEnglish (US)
Pages (from-to)550-556
Number of pages7
JournalArthritis & Rheumatism
Volume35
Issue number5
DOIs
StatePublished - May 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis'. Together they form a unique fingerprint.

  • Cite this