Cerebrospinal fluid and urinary biogenic amines in depressed patients and healthy controls

J. M. Davis, S. H. Koslow, R. D. Gibbons, J. W. Maas, C. L. Bowden, R. Casper, I. Hanin, J. I. Javaid, S. S. Chang, P. E. Stokes

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The National Institute of Mental Health-Clinical Research Branch Collaborative Study Investigated 132 drug-free, severely depressed patients and 80 healthy controls. Forty-five percent of the depressed patients excreted markedly elevated levels of urinary epinephrine (E) and metanephrine (MET), while only 5% of healthy controls did so. Using gaussian mixture distributions, we identified two subgroups of depressed patients: one excreting normal levels and the other excreting high levels of urinary E, MET, norepinephrine, and normetanephrine. Cerebrospinal fluid homovanillic acid levels were low in a subgroup of depressed patients. When analyzed by subgroup, the elevated E + MET group had markedly lower cerebrospinal fluid homovanillic acid levels than controls, whereas depressed patients with normal catecholamine levels did not. Since it has been postulated that there are two subgroups of depressed patients, those with low 3-methoxy-4-hydroxyphenylglycol (MHPG) levels and normal 5-hydroxyindoleacetic acid (5-HIAA) levels and those with normal MHPG levels and low 5-HIAA levels, several analyses were performed to see if such a group could be identified. Our analysis failed to find evidence of a subgroup of depressives with low MHPG and normal k-HIAA levels or normal MHPG and low 5-HIAA levels.

Original languageEnglish (US)
Pages (from-to)705-717
Number of pages13
JournalArchives of General Psychiatry
Volume45
Issue number8
StatePublished - 1988

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Biogenic Amines
Cerebrospinal Fluid
Metanephrine
Hydroxyindoleacetic Acid
Homovanillic Acid
Normetanephrine
National Institute of Mental Health (U.S.)
Normal Distribution
Epinephrine
Catecholamines
Norepinephrine
4-hydroxyphenethylene glycol
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Davis, J. M., Koslow, S. H., Gibbons, R. D., Maas, J. W., Bowden, C. L., Casper, R., ... Stokes, P. E. (1988). Cerebrospinal fluid and urinary biogenic amines in depressed patients and healthy controls. Archives of General Psychiatry, 45(8), 705-717.

Cerebrospinal fluid and urinary biogenic amines in depressed patients and healthy controls. / Davis, J. M.; Koslow, S. H.; Gibbons, R. D.; Maas, J. W.; Bowden, C. L.; Casper, R.; Hanin, I.; Javaid, J. I.; Chang, S. S.; Stokes, P. E.

In: Archives of General Psychiatry, Vol. 45, No. 8, 1988, p. 705-717.

Research output: Contribution to journalArticle

Davis, JM, Koslow, SH, Gibbons, RD, Maas, JW, Bowden, CL, Casper, R, Hanin, I, Javaid, JI, Chang, SS & Stokes, PE 1988, 'Cerebrospinal fluid and urinary biogenic amines in depressed patients and healthy controls', Archives of General Psychiatry, vol. 45, no. 8, pp. 705-717.
Davis JM, Koslow SH, Gibbons RD, Maas JW, Bowden CL, Casper R et al. Cerebrospinal fluid and urinary biogenic amines in depressed patients and healthy controls. Archives of General Psychiatry. 1988;45(8):705-717.
Davis, J. M. ; Koslow, S. H. ; Gibbons, R. D. ; Maas, J. W. ; Bowden, C. L. ; Casper, R. ; Hanin, I. ; Javaid, J. I. ; Chang, S. S. ; Stokes, P. E. / Cerebrospinal fluid and urinary biogenic amines in depressed patients and healthy controls. In: Archives of General Psychiatry. 1988 ; Vol. 45, No. 8. pp. 705-717.
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