Cerebral Vascular Response to Hypertonic Fluid Resuscitation in Thermal Injury

M. Barone, D. F. Jimenez, V. H. Huxley, X. F. Yang

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The purpose of this project was to study the effects of various resuscitation fluid protocols in a systemically thermally injured rat sustaining 70% body surface area third degree bum using the pial window model in rats. The results show that there was a significant albumin leak in the cerebral vessels in both the experimental group which underwent no resuscitation fluid, as well as the experimental group that was resuscitated with Lactated Ringer's solution using the Parkland formula. When this was compared to the control group, as well as to the experimental group which received hypertonic hyperosmotic saline (HMS) boluses every hour, there was little if any leakage seen.

Original languageEnglish (US)
Pages (from-to)265-266
Number of pages2
JournalActa Neurochirurgica, Supplement
Volume1997
Issue number70
DOIs
StatePublished - 1997

Keywords

  • Fluorescence isothiocyanate (FITC) albumin
  • Hypertonic hyperosmotic saline
  • Lactated Ringer's solution
  • Resuscitation
  • Thermal injury

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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