The purpose of this project was to study the effects of various resuscitation fluid protocols in a systemically thermally injured rat sustaining 70% body surface area third degree bum using the pial window model in rats. The results show that there was a significant albumin leak in the cerebral vessels in both the experimental group which underwent no resuscitation fluid, as well as the experimental group that was resuscitated with Lactated Ringer's solution using the Parkland formula. When this was compared to the control group, as well as to the experimental group which received hypertonic hyperosmotic saline (HMS) boluses every hour, there was little if any leakage seen.
- Fluorescence isothiocyanate (FITC) albumin
- Hypertonic hyperosmotic saline
- Lactated Ringer's solution
- Thermal injury
ASJC Scopus subject areas
- Clinical Neurology