Cerebral Vascular Response to Hypertonic Fluid Resuscitation in Thermal Injury

M. Barone; D. F. Jimenez; V. H. Huxley; X. F. Yang

doi:10.1007/978-3-7091-6837-0_82

Cerebral Vascular Response to Hypertonic Fluid Resuscitation in Thermal Injury

M. Barone, D. F. Jimenez, V. H. Huxley, X. F. Yang

Neurosurgery

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The purpose of this project was to study the effects of various resuscitation fluid protocols in a systemically thermally injured rat sustaining 70% body surface area third degree bum using the pial window model in rats. The results show that there was a significant albumin leak in the cerebral vessels in both the experimental group which underwent no resuscitation fluid, as well as the experimental group that was resuscitated with Lactated Ringer's solution using the Parkland formula. When this was compared to the control group, as well as to the experimental group which received hypertonic hyperosmotic saline (HMS) boluses every hour, there was little if any leakage seen.

Original language	English (US)
Pages (from-to)	265-266
Number of pages	2
Journal	Acta Neurochirurgica, Supplement
Volume	1997
Issue number	70
DOIs	https://doi.org/10.1007/978-3-7091-6837-0_82
State	Published - 1997

Keywords

Fluorescence isothiocyanate (FITC) albumin
Hypertonic hyperosmotic saline
Lactated Ringer's solution
Resuscitation
Thermal injury

ASJC Scopus subject areas

Surgery
Clinical Neurology

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