Cerebral salt wasting syndrome following brain injury in three pediatric patients: Suggestions for rapid diagnosis and therapy

John W. Berkenbosch, Christopher W. Lentz, David F. Jimenez, Joseph D. Tobias

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The association between hyponatremia and intracranial pathology has been well described. When accompanied by natriuresis, hyponatremia has most commonly been attributed to inappropriate secretion of antidiuretic hormone. However, there is growing evidence to suggest that many of these patients may actually have cerebrally mediated salt losses, a disorder referred to as the cerebral salt wasting syndrome (CSWS). While this syndrome has been reasonably well described in adults, data regarding CSWS in pediatric-aged patients remains sparse. Since fluid management of these disorders is different, it is important that the clinician be able to rapidly differentiate between them. We report three cases of CSWS in acutely brain-injured children and comment on the role that early quantitation of urine volume and urine sodium concentration had in rapidly establishing the correct diagnosis.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalPediatric Neurosurgery
Volume36
Issue number2
DOIs
StatePublished - Mar 25 2002

Keywords

  • Cerebral salt wasting
  • Hyponatremia
  • Pediatric WNatriuresis
  • SIADH
  • Urine volume

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

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