Cerebral phaeohyphomycosis caused by a dematiaceous scopulariopsis species

A. P. Hart, D. A. Sutton, P. J. McFeeley, M. Kornfeld

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


This report describes a rapidly fatal case of cerebral phaeohyphomycosis in a 33-year-old immunocompetent male. The infection presented as a single large lesion in the deep white matter of one temporal lobe, which was then removed surgically. Histologic features observed in the lobectomy specimen were characterized by perivascular sleeves of mononuclear cells accompanied by hemorrhages. These were reminiscent of acute hemorrhagic leukoencephalitis except for the presence of rare fungal organisms and sparse multinucleated giant cells similar to those occurring in AIDS. During the four days following surgery, a large focus of cerebritis with massive invasion of fungi developed in each centrum semiovale around the ventriculostomy sites. Fungal culture of the brain obtained at autopsy grew an organism consistent with a Scopulariopsis species.

Original languageEnglish (US)
Pages (from-to)224-228
Number of pages5
JournalClinical Neuropathology
Issue number5
StatePublished - 2001
Externally publishedYes


  • Cerebral phaeohyphomycosis
  • Fulminant encephalitis
  • Scopulariopsis species

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology


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