Cerebral modulation of circadian sleep-wake rhythms

James E. Jan, Urs Ribary, Peter K.H. Wong, Russel J. Reiter, Martin C.O. Bax, Michael B. Wasdell

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The objective of this prospective observational study was to assess the association between dysrhythmia of EEG background (disturbance of cerebral connectivity) and sleep difficulties. Sixty children, aged 4 to 12 years, participated. Hospital records were reviewed, and sleep histories were obtained by interviewing the parents. EEGs of 39 subjects were normal, showed epileptiform activity, and/or mild to moderate background dysrhythmia. Severe unilateral dysrhythmia was noted in 6 and bilaterally in 15 EEGs, with all 15 children having profound neurodevelopmental disabilities and 14 of these 15 having long-standing severe chaotic sleep/wake patterns. Thus, there was a highly significant association between EEG evidence of severe bilateral dysrhythmia and chronic sleep/wake dysregulation. Unilateral dysrhythmia was not associated with sleep difficulties. This study delineates a specific sleep disorder in a group of children with marked neurodevelopmental disabilities and offers insight into how disturbed cerebral connectivity impacts the thalamocortical dynamics relating to neurodevelopmental disabilities, sleep, and melatonin production.

Original languageEnglish (US)
Pages (from-to)165-169
Number of pages5
JournalJournal of Clinical Neurophysiology
Issue number2
StatePublished - Apr 2011


  • Children
  • EEG
  • Epilepsy
  • Melatonin
  • Neurodevelopmental disability
  • Sleep disorders

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Physiology


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