TY - JOUR
T1 - Cerebral deep venous thrombosis and COVID-19
T2 - Case report
AU - Hoelscher, Christian
AU - Sweid, Ahmad
AU - Ghosh, Ritam
AU - Al Saiegh, Fadi
AU - Keppetipola, Kavantissa M.
AU - Farrell, Christopher J.
AU - Jallo, Jack
AU - Jabbour, Pascal
AU - Tjoumakaris, Stavropoula
AU - Gooch, M. Reid
AU - Rosenwasser, Robert H.
AU - Shah, Syed O.
N1 - Publisher Copyright:
© AANS 2021.
PY - 2021/7
Y1 - 2021/7
N2 - Herein, the authors present the case of a 54-year-old male diagnosed with coronavirus disease 2019 (COVID-19) during a screening test. The patient was asked to self-isolate at home and report with any exacerbations of symptoms. He presented later with pneumonia complicated by encephalopathy at days 14 and 15 from initial diagnosis, respectively. MRI of the brain showed bithalamic and gangliocapsular FLAIR signal abnormality with mild right-sided thalamic and periventricular diffusion restriction. A CT venogram was obtained given the distribution of edema and demonstrated deep venous thrombosis involving the bilateral internal cerebral veins and the vein of Galen. CSF workup was negative for encephalitis, as the COVID-19 polymerase chain reaction (PCR) test and bacterial cultures were negative. A complete hypercoagulable workup was negative, and the venous thrombosis was attributed to a hypercoagulable state induced by COVID-19. The mental decline was attributed to bithalamic and gangliocapsular venous infarction secondary to deep venous thrombosis. Unfortunately, the patient’s condition continued to decline, and care was withdrawn.
AB - Herein, the authors present the case of a 54-year-old male diagnosed with coronavirus disease 2019 (COVID-19) during a screening test. The patient was asked to self-isolate at home and report with any exacerbations of symptoms. He presented later with pneumonia complicated by encephalopathy at days 14 and 15 from initial diagnosis, respectively. MRI of the brain showed bithalamic and gangliocapsular FLAIR signal abnormality with mild right-sided thalamic and periventricular diffusion restriction. A CT venogram was obtained given the distribution of edema and demonstrated deep venous thrombosis involving the bilateral internal cerebral veins and the vein of Galen. CSF workup was negative for encephalitis, as the COVID-19 polymerase chain reaction (PCR) test and bacterial cultures were negative. A complete hypercoagulable workup was negative, and the venous thrombosis was attributed to a hypercoagulable state induced by COVID-19. The mental decline was attributed to bithalamic and gangliocapsular venous infarction secondary to deep venous thrombosis. Unfortunately, the patient’s condition continued to decline, and care was withdrawn.
KW - COVID-19
KW - Central nervous system
KW - Cerebrovascular disease
KW - Deep venous thrombosis
KW - Hypercoagulable state
KW - Infection
KW - SARS-CoV-2
KW - Vascular disorders
UR - http://www.scopus.com/inward/record.url?scp=85109134170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85109134170&partnerID=8YFLogxK
U2 - 10.3171/2020.5.JNS201542
DO - 10.3171/2020.5.JNS201542
M3 - Article
C2 - 32886922
AN - SCOPUS:85109134170
SN - 0022-3085
VL - 135
SP - 17
EP - 20
JO - Journal of neurosurgery
JF - Journal of neurosurgery
IS - 1
ER -