Central renal stab wounds: Treatment with augmented fibrin sealant in a porcine model

Brian C. Griffith, Allen F. Morey, Thomas A. Rozanski, Richard Harris, Scott R. Dalton, Sigurd J. Torgerson, Scott R. Partyka

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Purpose: We determined whether fibrin sealant augmented by an absorbable bolster could salvage kidneys with major, centrally located stab wounds. Materials and Methods: A grade 4 renal injury was created in 16 commercial swine via a 1.5 cm sagittal, centrally located, through-and-through right renal laceration. Animals were randomized to 1 of 4 treatment arms, including control groups that received conventional renal capsule suture repair with an absorbable gelatin sponge bolster (3 in group 1) or a microfibrillar collagen sheet (3 in group 2) and experimental groups that received sutureless treatment entailing fibrin sealant instillation into the knife tract augmented by an external gelatin sponge (5 in group 3) or an external microfibrillar collagen sheet (5 in group 4). Arterial occlusion was not performed. Blood loss and time to hemostasis were recorded. Abdominal computerized tomography was performed at 1 week and necropsy was done at 6 weeks. Results: Renal reconstruction with fibrin sealant resulted in significantly lower blood loss (62 vs 155 ml, p <0.05) and time to hemostasis (3.5 vs 6.5 minutes, p <0.05) than in the conventional suture groups. There was no radiographic or gross evidence of significant postoperative bleeding, urinoma formation or abnormal tissue healing in the recovery period. Gelatin sponge and collagen sheet demonstrated similar hemostatic efficacy. Conclusions: In this porcine renal trauma model fibrin sealant augmented by absorbable gelatin sponge or a microfibrillar collagen sheet effectively promoted hemostasis and renal salvage. Because of its safety, ease of use and efficiency, fibrin sealant appears to be an appropriate adjunct for managing challenging renal injuries.

Original languageEnglish (US)
Pages (from-to)445-447
Number of pages3
JournalJournal of Urology
Volume171
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • Fibrin tissue adhesive
  • Kidney
  • Swine
  • Wounds, penetrating

ASJC Scopus subject areas

  • Urology

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    Griffith, B. C., Morey, A. F., Rozanski, T. A., Harris, R., Dalton, S. R., Torgerson, S. J., & Partyka, S. R. (2004). Central renal stab wounds: Treatment with augmented fibrin sealant in a porcine model. Journal of Urology, 171(1), 445-447. https://doi.org/10.1097/01.ju.0000101000.08371.79