Central hypogonadism in burned men

Stephen R. Plymate, George M. Vaughan, Arthur D. Mason, Basil A. Pruitt

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Serum samples were obtained from 30 burned men at different times up to the fourth month after injury. Mean concentrations of estradiol (E2) were elevated above those for healthycontrol subjects. Mean serum total testosterone (T), sex hormone-binding globulin (SHBG), bioassayable luteinizing hormone (LH), thyroxine (T4), triiodothyronine (T3) and their free indices (FT4I and FT3I) were depressed below those of controls during the first postburn week. Mean values for T and LH were progressively higher in samples taken from later time periods but remained depressed. Mean SHBG and thyroid hormones rose and were not significantly different from control values during later periods of the study. Calculated non-SHBG-bound T (NSBT) was below normal in each time period. The close correlation of SHBG values with those of T3 and FT3I in the patients suggests that SHBG responds to the altered thyroid hormone milieu of bum injury. It is postulated that elevated serum E2 perhaps from adrenal precursors promotes an alteration of hypothalamic function resulting in a markedly reduced secretion of bioactive LH and diminished Leydig cell function.

Original languageEnglish (US)
Pages (from-to)152-158
Number of pages7
JournalHormone Research in Paediatrics
Issue number3
StatePublished - 1987


  • Bioactivity
  • Burns
  • Estradiol
  • Luteinizing hormone
  • Sex hormone-binding globulin
  • Testosterone
  • Thyroid hormones

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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