Central hypogonadism in burned men

S. R. Plymate, G. M. Vaughan, A. D. Mason, Basil A Pruitt

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Serum samples were obtained from 30 burned men at different times up to the fourth month after injury. Mean concentrations of estradiol (E2) were elevated above those for healthy control subjects. Mean serum total testosterone (T), sex hormone-binding globulin (SHBG), bioassayable luteininzing hormone (LH), thyroxine (T4), triiodothyronine (T3) and their free indices (FI4T and FT3I) were depressed below those of controls during the first postburn week. Mean values for T and LH were progressively higher in samples taken from late time periods but remained depressed. Mean SHBG and thyroid hormones rose and were not significantly different from control values during later periods of the study. Calculated non-SHBG-bound T (NSBT) was below normal in each time period. The close correlation of SHBG values with those of T3 and FT3I in the patients suggests that SHBG responds to the altered thyroid hormone milieu of burn injury. It is postulated that elevated serum E2 perhaps from adrenal precursors promotes an alteration of hypothalamic function resulting in a markedly reduced secretion of bioactive LH and diminshed Leydig cell function.

Original languageEnglish (US)
Pages (from-to)152-158
Number of pages7
JournalHormone Research
Volume27
Issue number3
StatePublished - 1987
Externally publishedYes

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Sex Hormone-Binding Globulin
Hypogonadism
Hormones
Thyroid Hormones
Serum
Leydig Cells
Wounds and Injuries
Triiodothyronine
Thyroxine
Testosterone
Estradiol
Healthy Volunteers

ASJC Scopus subject areas

  • Endocrinology

Cite this

Plymate, S. R., Vaughan, G. M., Mason, A. D., & Pruitt, B. A. (1987). Central hypogonadism in burned men. Hormone Research, 27(3), 152-158.

Central hypogonadism in burned men. / Plymate, S. R.; Vaughan, G. M.; Mason, A. D.; Pruitt, Basil A.

In: Hormone Research, Vol. 27, No. 3, 1987, p. 152-158.

Research output: Contribution to journalArticle

Plymate, SR, Vaughan, GM, Mason, AD & Pruitt, BA 1987, 'Central hypogonadism in burned men', Hormone Research, vol. 27, no. 3, pp. 152-158.
Plymate SR, Vaughan GM, Mason AD, Pruitt BA. Central hypogonadism in burned men. Hormone Research. 1987;27(3):152-158.
Plymate, S. R. ; Vaughan, G. M. ; Mason, A. D. ; Pruitt, Basil A. / Central hypogonadism in burned men. In: Hormone Research. 1987 ; Vol. 27, No. 3. pp. 152-158.
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