Abstract
Physiological responses to perturbations of the external environment or systemic milieu are mediated at the cellular level via complex systems of intracellular signals generated by agonists acting at cell surface or nuclear receptors. Disturbances of cellular signal transduction pathways have been observed during aging and invoked in mechanisms underlying age-related physiological dysfunction, processes controlling longevity, and pathogenesis of diseases prevalent in older individuals. In this entry we review the current state of knowledge regarding age-associated changes of cellular signaling linked to guanine nucleotide binding protein-coupled receptors, receptor tyrosine kinases (including the insulin receptor) and other receptors mediating anabolic responses, and steroid hormone receptors. We also discuss how the delineation of signaling changes during aging constitutes an ongoing rationale for the development of novel therapeutics aimed at health maintenance and disease prevention and treatment in later life.
| Original language | English (US) |
|---|---|
| Title of host publication | Encyclopedia of Biomedical Gerontology |
| Subtitle of host publication | Volume 1-3 |
| Publisher | Elsevier |
| Pages | V1-371-V1-379 |
| Volume | 1 |
| ISBN (Electronic) | 9780128160763 |
| DOIs | |
| State | Published - Jan 1 2019 |
Keywords
- Cross-talk
- Epidermal growth factor receptor
- G-protein coupled receptor (GPCR)
- GPCR kinase (GRK)
- Insulin
- Notch signaling
- Receptor tyrosine kinase
- Steroid hormones
- Thyroid hormones
- β-Arrestin
ASJC Scopus subject areas
- General Medicine