Cellular senescence and radiation-induced pulmonary fibrosis

Yonghan He, Dinesh Thummuri, Guangrong Zheng, Paul Okunieff, Deborah E. Citrin, Zeljko Vujaskovic, Daohong Zhou

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

Radiation-induced pulmonary fibrosis (RIPF)is a serious treatment complication that affects about 9%–30% cancer patients receiving radiotherapy for thoracic tumors. RIPF is characterized by progressive and irreversible destruction of lung tissues and deterioration of lung function, which can compromise quality of life and eventually lead to respiratory failure and death. Unfortunately, the mechanisms by which radiation causes RIPF have not been well established nor has an effective treatment for RIPF been developed. Recently, an increasing body of evidence suggests that induction of senescence by radiation may play an important role in RIPF and clearance of senescent cells (SnCs)with a senolytic agent, small molecule that can selectively kill SnCs, has the potential to be developed as a novel therapeutic strategy for RIPF. This review discusses some of these new findings to promote further study on the role of cellular senescence in RIPF and the development of senolytic therapeutics for RIPF.

Original languageEnglish (US)
Pages (from-to)14-21
Number of pages8
JournalTranslational Research
Volume209
DOIs
StatePublished - Jul 2019
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Physiology (medical)
  • Biochemistry, medical

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