Cellular replicative capacity correlates primarily with species body mass not longevity

Antonello Lorenzini, Maria Tresini, Steven N. Austad, Vincent J. Cristofalo

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Although the limited replicative capacity of human fibroblasts in culture is frequently used as a model for aging, a question of major interest is whether the relationship between in vitro fibroblast proliferative capacity and species longevity is primary or secondary to a relationship with species body size. In this report we establish that body mass is the primary correlative of proliferative potential rather than species life-span.

Original languageEnglish (US)
Pages (from-to)1130-1133
Number of pages4
JournalMechanisms of Ageing and Development
Volume126
Issue number10
DOIs
StatePublished - Oct 1 2005

Keywords

  • Aging
  • Body mass
  • Fibroblast
  • Longevity
  • Replicative senescence

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

Fingerprint Dive into the research topics of 'Cellular replicative capacity correlates primarily with species body mass not longevity'. Together they form a unique fingerprint.

Cite this