Cellular immunity to the mouse pneumonitis agent

D. M. Williams, J. Schachter, J. J. Coalson, B. Grubbs

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

During infection with the mouse pneumonitis biovar of Chlamydia trachomatis, heterozygous (nu/+) mice with relatively intact T cell function develop both delayed hypersensitivity to C trachomatis antigen and antigen-specific lymphocytes transformation, whereas athymic nude (nu/nu) mice do not. Nu/nu mice are protected against death from mouse pneumonitis by transfer of immune T cells from nu/+ mice, which are more resistant to C trachomatis. While this enables athymic mice to make antibody to C trachomatis (which does not occur without reconstitution), resistance correlates best with development of antigen-specific lymphocyte transformation in the recipient animals. During infection nu/+ mice develop activated alveolar macrophages (by both morphological and functional criteria) while nu/nu mice do not. Nu/+ mice that have been preinfected with Histoplasma capsulatum to activate cellular immunity become more resistant to C trachomatis than do nu/+ controls. Cell-mediated immunity to C trachomatis pneumonia is T cell dependent and is important in host defense.

Original languageEnglish (US)
Pages (from-to)630-639
Number of pages10
JournalJournal of Infectious Diseases
Volume149
Issue number4
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Williams, D. M., Schachter, J., Coalson, J. J., & Grubbs, B. (1984). Cellular immunity to the mouse pneumonitis agent. Journal of Infectious Diseases, 149(4), 630-639. https://doi.org/10.1093/infdis/149.4.630