Abstract
Avian erythroblastosis virus, a retrovirus that causes erythroblastosis and sarcomas in infected birds, possesses two host cell-derived genes [viral (v) erb-A and erb-B]. Although v-erb-B seems to be responsible for oncogenic transformation, v-erb-A might have an enhancing effect on transformation. In chickens, the natural host for avian erythroblastosis virus, cellular (c) erb-A and erb-B genes appear to be unlinked, but their chromosomal locations in other species are unknown. To ascertain the chromosomal location of c-erb genes in man and mouse, we analyzed interspecies somatic cell and microcell hybrids by Southern filter hybridization techniques using specific v-erb-A and v-erb-B probes. We found c-erb-A sequences on human chromosome 17 (17p11 → qter) and located c-erb-B on human chromosome 7 (7pter → q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4874-4878 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 81 |
| Issue number | 15 I |
| State | Published - 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
- General
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Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man. / Zabel, B. U.; Fournier, R. E.; Lalley, P. A.; Naylor, S. L.; Sakaguchi, Alan Y.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, No. 15 I, 1984, p. 4874-4878.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man
AU - Zabel, B. U.
AU - Fournier, R. E.
AU - Lalley, P. A.
AU - Naylor, S. L.
AU - Sakaguchi, Alan Y
PY - 1984
Y1 - 1984
N2 - Avian erythroblastosis virus, a retrovirus that causes erythroblastosis and sarcomas in infected birds, possesses two host cell-derived genes [viral (v) erb-A and erb-B]. Although v-erb-B seems to be responsible for oncogenic transformation, v-erb-A might have an enhancing effect on transformation. In chickens, the natural host for avian erythroblastosis virus, cellular (c) erb-A and erb-B genes appear to be unlinked, but their chromosomal locations in other species are unknown. To ascertain the chromosomal location of c-erb genes in man and mouse, we analyzed interspecies somatic cell and microcell hybrids by Southern filter hybridization techniques using specific v-erb-A and v-erb-B probes. We found c-erb-A sequences on human chromosome 17 (17p11 → qter) and located c-erb-B on human chromosome 7 (7pter → q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11.
AB - Avian erythroblastosis virus, a retrovirus that causes erythroblastosis and sarcomas in infected birds, possesses two host cell-derived genes [viral (v) erb-A and erb-B]. Although v-erb-B seems to be responsible for oncogenic transformation, v-erb-A might have an enhancing effect on transformation. In chickens, the natural host for avian erythroblastosis virus, cellular (c) erb-A and erb-B genes appear to be unlinked, but their chromosomal locations in other species are unknown. To ascertain the chromosomal location of c-erb genes in man and mouse, we analyzed interspecies somatic cell and microcell hybrids by Southern filter hybridization techniques using specific v-erb-A and v-erb-B probes. We found c-erb-A sequences on human chromosome 17 (17p11 → qter) and located c-erb-B on human chromosome 7 (7pter → q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021239175&partnerID=8YFLogxK
M3 - Article
C2 - 6087351
AN - SCOPUS:0021239175
VL - 81
SP - 4874
EP - 4878
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 15 I
ER -