TY - JOUR
T1 - Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man
AU - Zabel, B. U.
AU - Fournier, R. E.
AU - Lalley, P. A.
AU - Naylor, S. L.
AU - Sakaguchi, A. Y.
PY - 1984/1/1
Y1 - 1984/1/1
N2 - Avian erythroblastosis virus, a retrovirus that causes erythroblastosis and sarcomas in infected birds, possesses two host cell-derived genes [viral (v) erb-A and erb-B]. Although v-erb-B seems to be responsible for oncogenic transformation, v-erb-A might have an enhancing effect on transformation. In chickens, the natural host for avian erythroblastosis virus, cellular (c) erb-A and erb-B genes appear to be unlinked, but their chromosomal locations in other species are unknown. To ascertain the chromosomal location of c-erb genes in man and mouse, we analyzed interspecies somatic cell and microcell hybrids by Southern filter hybridization techniques using specific v-erb-A and v-erb-B probes. We found c-erb-A sequences on human chromosome 17 (17p11 → qter) and located c-erb-B on human chromosome 7 (7pter → q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11.
AB - Avian erythroblastosis virus, a retrovirus that causes erythroblastosis and sarcomas in infected birds, possesses two host cell-derived genes [viral (v) erb-A and erb-B]. Although v-erb-B seems to be responsible for oncogenic transformation, v-erb-A might have an enhancing effect on transformation. In chickens, the natural host for avian erythroblastosis virus, cellular (c) erb-A and erb-B genes appear to be unlinked, but their chromosomal locations in other species are unknown. To ascertain the chromosomal location of c-erb genes in man and mouse, we analyzed interspecies somatic cell and microcell hybrids by Southern filter hybridization techniques using specific v-erb-A and v-erb-B probes. We found c-erb-A sequences on human chromosome 17 (17p11 → qter) and located c-erb-B on human chromosome 7 (7pter → q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11.
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U2 - 10.1073/pnas.81.15.4874
DO - 10.1073/pnas.81.15.4874
M3 - Article
C2 - 6087351
AN - SCOPUS:0021239175
VL - 81
SP - 4874
EP - 4878
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 15 I
ER -