Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man

B. U. Zabel, R. E. Fournier, P. A. Lalley, S. L. Naylor, Alan Y Sakaguchi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Avian erythroblastosis virus, a retrovirus that causes erythroblastosis and sarcomas in infected birds, possesses two host cell-derived genes [viral (v) erb-A and erb-B]. Although v-erb-B seems to be responsible for oncogenic transformation, v-erb-A might have an enhancing effect on transformation. In chickens, the natural host for avian erythroblastosis virus, cellular (c) erb-A and erb-B genes appear to be unlinked, but their chromosomal locations in other species are unknown. To ascertain the chromosomal location of c-erb genes in man and mouse, we analyzed interspecies somatic cell and microcell hybrids by Southern filter hybridization techniques using specific v-erb-A and v-erb-B probes. We found c-erb-A sequences on human chromosome 17 (17p11 → qter) and located c-erb-B on human chromosome 7 (7pter → q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11.

Original languageEnglish (US)
Pages (from-to)4874-4878
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume81
Issue number15 I
StatePublished - 1984
Externally publishedYes

Fingerprint

Alpharetrovirus
Human Chromosomes
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 7
Viral Genes
Hybrid Cells
Retroviridae
Sarcoma
Genes
Birds
Chickens

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man. / Zabel, B. U.; Fournier, R. E.; Lalley, P. A.; Naylor, S. L.; Sakaguchi, Alan Y.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, No. 15 I, 1984, p. 4874-4878.

Research output: Contribution to journalArticle

@article{f2b4dd5229ba4bc19407894646cf1fdc,
title = "Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man",
abstract = "Avian erythroblastosis virus, a retrovirus that causes erythroblastosis and sarcomas in infected birds, possesses two host cell-derived genes [viral (v) erb-A and erb-B]. Although v-erb-B seems to be responsible for oncogenic transformation, v-erb-A might have an enhancing effect on transformation. In chickens, the natural host for avian erythroblastosis virus, cellular (c) erb-A and erb-B genes appear to be unlinked, but their chromosomal locations in other species are unknown. To ascertain the chromosomal location of c-erb genes in man and mouse, we analyzed interspecies somatic cell and microcell hybrids by Southern filter hybridization techniques using specific v-erb-A and v-erb-B probes. We found c-erb-A sequences on human chromosome 17 (17p11 → qter) and located c-erb-B on human chromosome 7 (7pter → q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11.",
author = "Zabel, {B. U.} and Fournier, {R. E.} and Lalley, {P. A.} and Naylor, {S. L.} and Sakaguchi, {Alan Y}",
year = "1984",
language = "English (US)",
volume = "81",
pages = "4874--4878",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "15 I",

}

TY - JOUR

T1 - Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man

AU - Zabel, B. U.

AU - Fournier, R. E.

AU - Lalley, P. A.

AU - Naylor, S. L.

AU - Sakaguchi, Alan Y

PY - 1984

Y1 - 1984

N2 - Avian erythroblastosis virus, a retrovirus that causes erythroblastosis and sarcomas in infected birds, possesses two host cell-derived genes [viral (v) erb-A and erb-B]. Although v-erb-B seems to be responsible for oncogenic transformation, v-erb-A might have an enhancing effect on transformation. In chickens, the natural host for avian erythroblastosis virus, cellular (c) erb-A and erb-B genes appear to be unlinked, but their chromosomal locations in other species are unknown. To ascertain the chromosomal location of c-erb genes in man and mouse, we analyzed interspecies somatic cell and microcell hybrids by Southern filter hybridization techniques using specific v-erb-A and v-erb-B probes. We found c-erb-A sequences on human chromosome 17 (17p11 → qter) and located c-erb-B on human chromosome 7 (7pter → q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11.

AB - Avian erythroblastosis virus, a retrovirus that causes erythroblastosis and sarcomas in infected birds, possesses two host cell-derived genes [viral (v) erb-A and erb-B]. Although v-erb-B seems to be responsible for oncogenic transformation, v-erb-A might have an enhancing effect on transformation. In chickens, the natural host for avian erythroblastosis virus, cellular (c) erb-A and erb-B genes appear to be unlinked, but their chromosomal locations in other species are unknown. To ascertain the chromosomal location of c-erb genes in man and mouse, we analyzed interspecies somatic cell and microcell hybrids by Southern filter hybridization techniques using specific v-erb-A and v-erb-B probes. We found c-erb-A sequences on human chromosome 17 (17p11 → qter) and located c-erb-B on human chromosome 7 (7pter → q22). In contrast, both c-erb-A and c-erb-B reside on mouse chromosome 11.

UR - http://www.scopus.com/inward/record.url?scp=0021239175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021239175&partnerID=8YFLogxK

M3 - Article

C2 - 6087351

AN - SCOPUS:0021239175

VL - 81

SP - 4874

EP - 4878

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 15 I

ER -