Cell junctions and intercellular communication

J. P. Revel, S. B. Yancey, D. J. Meyer, B. Nicholson

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

We have compared intercellular communication in normal and regenerating rat liver. Gap junctions are greatly reduced in size and numbers 29 to 35 hr after hepatectomy, but we still find some 90% of hepatocytes coupled by electrophysiological criteria. The spread of dyes such as carboxyfluorescein however is very limited in the regenerating organs as compared to the situation in the controls. We show how the apparent discrepancies between morphological and physiological data can be reconciled. We also present a summary of preliminary findings on the biosynthesis of gap junction protein and some of the conclusions one can draw from the sequence of 58 amino acids at the amino terminal of the protein.

Original languageEnglish (US)
Pages (from-to)1010-1017
Number of pages8
JournalIn Vitro
Volume16
Issue number12
DOIs
StatePublished - Dec 1980
Externally publishedYes

Keywords

  • freeze fracture
  • gap junctions
  • intercellular communication
  • junctional proteins
  • liver
  • regenerating liver

ASJC Scopus subject areas

  • Biotechnology
  • Plant Science

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