Cell-Based Therapy for Ischemic Heart Disease: A Clinical Update

Jeremy L. Herrmann, Aaron M. Abarbanell, Brent R. Weil, Yue Wang, Meijing Wang, Jiangning Tan, Daniel R. Meldrum

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Progenitor cell therapy is a promising treatment for ischemic heart disease. Early clinical trials of autologous bone marrow-derived progenitor cell therapy for acute and chronic myocardial ischemia showed modest functional improvements after cell delivery; however, the duration of these benefits remains unclear. Ongoing investigations continue to enhance our understanding of the mechanisms by which progenitor and stem cells function and how their survival and cardioprotective abilities can be improved. This review discusses: (1) relevant progenitor and stem cells in myocardial regenerative therapy, (2) routes of cell delivery to ischemic myocardium, (3) clinical trials investigating bone marrow-derived progenitor cell therapy for myocardial ischemia, and (4) future directions of the field.

Original languageEnglish (US)
Pages (from-to)1714-1722
Number of pages9
JournalAnnals of Thoracic Surgery
Issue number5
StatePublished - Nov 2009
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery


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