cDNAs Encoding Members of a Family of Proteins Related to Human Sterol Carrier Protein 2 and Assignment of the Gene to Human Chromosome 1 p21→pter

Zhigang he, Ritsu Yamamoto, Emma E. Furth, Laura J. Schantz, Susan L. Naylor, Henry George, Jeffrey T. Billheimer, Jerome F. Strauss

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Sterol carrier protein 2 (SCP2) is believed to play a key role in intracellular lipid movement. Here we report the cloning and nucleotide sequences of cDNAs encoding SCP2-related proteins of 58.85 kD and 30.8 kD and the assignment of the SCP2 gene to human chromosome 1 p21-pter. The SCP2-related proteins share common deduced carboxyl amino acid sequences with SCP2 and the cDNAs have a common 3′ untranslated nucleotide sequence. The mRNAs encoding these proteins increased in a coordinate fashion as human placental cytotrophoblasts differentiated into syncytiotrophoblasts in culture. Our observations document the existence of a family of related proteins encoded by the human SCP2 gene.

Original languageEnglish (US)
Pages (from-to)559-569
Number of pages11
JournalDNA and Cell Biology
Volume10
Issue number8
DOIs
StatePublished - Oct 1991
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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