CD56-positive large B-cell lymphoma

James Weisberger, Wojciech Gorczyca, Marsha C Kinney

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

CD56 (NCAM), a neural adhesion molecule, is normally expressed on natural killer cells and subsets of T cells and is commonly seen on hematolymphoid neoplasms such as plasma cell myeloma and acute myelogenous leukemia. It is uncommon in B-cell lymphoma. From 2001 to 2003 a cohort of 20 cases of CD56 B-cell lymphomas was identified by flow cytometry (<0.5% of all B-cell lymphomas studied) during a 2-year period. Most (90%) expressed CD10 and 5/5 tested cases were BCL6, suggesting a follicular origin. An extranodal disease presentation was seen in 45% and may be related to CD56 expression. These CD56 B-cell lymphomas may represent a new subset of large B-cell lymphoma. The relationship of cells with this antigenic profile to normal B-cell differentiation is explored.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalApplied Immunohistochemistry and Molecular Morphology
Volume14
Issue number4
DOIs
StatePublished - Dec 2006

Fingerprint

B-Cell Lymphoma
Neural Cell Adhesion Molecules
Multiple Myeloma
Acute Myeloid Leukemia
Natural Killer Cells
Cell Differentiation
Flow Cytometry
B-Lymphocytes
T-Lymphocytes
Neoplasms

Keywords

  • B cell
  • CD56
  • Flow cytometry
  • Immunohistochemistry
  • Immunophoenotyping

ASJC Scopus subject areas

  • Anatomy
  • Medical Laboratory Technology

Cite this

CD56-positive large B-cell lymphoma. / Weisberger, James; Gorczyca, Wojciech; Kinney, Marsha C.

In: Applied Immunohistochemistry and Molecular Morphology, Vol. 14, No. 4, 12.2006, p. 369-374.

Research output: Contribution to journalArticle

Weisberger, James ; Gorczyca, Wojciech ; Kinney, Marsha C. / CD56-positive large B-cell lymphoma. In: Applied Immunohistochemistry and Molecular Morphology. 2006 ; Vol. 14, No. 4. pp. 369-374.
@article{0986ece9297a4b76865392c9c3c92cb0,
title = "CD56-positive large B-cell lymphoma",
abstract = "CD56 (NCAM), a neural adhesion molecule, is normally expressed on natural killer cells and subsets of T cells and is commonly seen on hematolymphoid neoplasms such as plasma cell myeloma and acute myelogenous leukemia. It is uncommon in B-cell lymphoma. From 2001 to 2003 a cohort of 20 cases of CD56 B-cell lymphomas was identified by flow cytometry (<0.5{\%} of all B-cell lymphomas studied) during a 2-year period. Most (90{\%}) expressed CD10 and 5/5 tested cases were BCL6, suggesting a follicular origin. An extranodal disease presentation was seen in 45{\%} and may be related to CD56 expression. These CD56 B-cell lymphomas may represent a new subset of large B-cell lymphoma. The relationship of cells with this antigenic profile to normal B-cell differentiation is explored.",
keywords = "B cell, CD56, Flow cytometry, Immunohistochemistry, Immunophoenotyping",
author = "James Weisberger and Wojciech Gorczyca and Kinney, {Marsha C}",
year = "2006",
month = "12",
doi = "10.1097/01.pai.0000208279.66189.43",
language = "English (US)",
volume = "14",
pages = "369--374",
journal = "Applied Immunohistochemistry and Molecular Morphology",
issn = "1541-2016",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - CD56-positive large B-cell lymphoma

AU - Weisberger, James

AU - Gorczyca, Wojciech

AU - Kinney, Marsha C

PY - 2006/12

Y1 - 2006/12

N2 - CD56 (NCAM), a neural adhesion molecule, is normally expressed on natural killer cells and subsets of T cells and is commonly seen on hematolymphoid neoplasms such as plasma cell myeloma and acute myelogenous leukemia. It is uncommon in B-cell lymphoma. From 2001 to 2003 a cohort of 20 cases of CD56 B-cell lymphomas was identified by flow cytometry (<0.5% of all B-cell lymphomas studied) during a 2-year period. Most (90%) expressed CD10 and 5/5 tested cases were BCL6, suggesting a follicular origin. An extranodal disease presentation was seen in 45% and may be related to CD56 expression. These CD56 B-cell lymphomas may represent a new subset of large B-cell lymphoma. The relationship of cells with this antigenic profile to normal B-cell differentiation is explored.

AB - CD56 (NCAM), a neural adhesion molecule, is normally expressed on natural killer cells and subsets of T cells and is commonly seen on hematolymphoid neoplasms such as plasma cell myeloma and acute myelogenous leukemia. It is uncommon in B-cell lymphoma. From 2001 to 2003 a cohort of 20 cases of CD56 B-cell lymphomas was identified by flow cytometry (<0.5% of all B-cell lymphomas studied) during a 2-year period. Most (90%) expressed CD10 and 5/5 tested cases were BCL6, suggesting a follicular origin. An extranodal disease presentation was seen in 45% and may be related to CD56 expression. These CD56 B-cell lymphomas may represent a new subset of large B-cell lymphoma. The relationship of cells with this antigenic profile to normal B-cell differentiation is explored.

KW - B cell

KW - CD56

KW - Flow cytometry

KW - Immunohistochemistry

KW - Immunophoenotyping

UR - http://www.scopus.com/inward/record.url?scp=33751366308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751366308&partnerID=8YFLogxK

U2 - 10.1097/01.pai.0000208279.66189.43

DO - 10.1097/01.pai.0000208279.66189.43

M3 - Article

VL - 14

SP - 369

EP - 374

JO - Applied Immunohistochemistry and Molecular Morphology

JF - Applied Immunohistochemistry and Molecular Morphology

SN - 1541-2016

IS - 4

ER -