CD56-positive large B-cell lymphoma

James Weisberger, Wojciech Gorczyca, Marsha C. Kinney

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

CD56 (NCAM), a neural adhesion molecule, is normally expressed on natural killer cells and subsets of T cells and is commonly seen on hematolymphoid neoplasms such as plasma cell myeloma and acute myelogenous leukemia. It is uncommon in B-cell lymphoma. From 2001 to 2003 a cohort of 20 cases of CD56 B-cell lymphomas was identified by flow cytometry (<0.5% of all B-cell lymphomas studied) during a 2-year period. Most (90%) expressed CD10 and 5/5 tested cases were BCL6, suggesting a follicular origin. An extranodal disease presentation was seen in 45% and may be related to CD56 expression. These CD56 B-cell lymphomas may represent a new subset of large B-cell lymphoma. The relationship of cells with this antigenic profile to normal B-cell differentiation is explored.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalApplied Immunohistochemistry and Molecular Morphology
Volume14
Issue number4
DOIs
StatePublished - Dec 1 2006

Keywords

  • B cell
  • CD56
  • Flow cytometry
  • Immunohistochemistry
  • Immunophoenotyping

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology

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