CD30 (Ki‐1) positive anaplastic large cell lymphomas in individuals infected with the human immunodeficiency virus

Amy Chadburn, Ethel Cesarman, Jaishree Jagirdar, Milayna Subar, Rabia N. Mir, Daniel M. Knowles

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


Background. CD30 (Ki‐1) positive anaplastic large cell lymphoma (ALCL) has been only rarely described in HIV‐positive patients. Methods. The clinicopathologic features of eight ALCLs occurring in four AIDS and four HIV‐positive patients were investigated. The phenotype of each neoplasm was determined by immunohistochemical methods. In three cases fresh tissue was available for molecular analysis. Results. The ALCLs are a clinically heterogeneous group of T (4), B (1) and indeterminate (3) cell malignant lymphomas which presented in the skin (4), liver (1), lung (1), nasal cavity (1; also with bone marrow involvement) and peritoneal fluid (1). While most of the patients had aggressive disease, dying in a median of three months, two patients had either localized or regressing skin lesions. Molecular studies showed that two ALCLs, one of B cell and one of indeterminate cell lineage, contained clonal Epstein‐Barr virus sequences. None of the ALCLs examined contained evidence of HTLV‐1 or HIV integration nor did they exhibit c‐myc or bcl‐2 proto‐oncogene rearrangements. No mutations or deletions of the p53 tumor suppressor gene were identified in the three cases studied. Conclusions. HIV‐related ALCL represents a clinically heterogeneous group of T cell, B cell and null cell malignant lymphomas, distinct from the previously described categories of AIDS‐associated NHL, that may expand the spectrum of lymphoid neoplasms associated with HIV‐infection. Identification and investigation of other cases of HIV‐associated ALCL is important to determine the nature of the relationship between HIV infection and the development of ALCL.

Original languageEnglish (US)
Pages (from-to)3078-3090
Number of pages13
Issue number10
StatePublished - Nov 15 1993
Externally publishedYes


  • CD30
  • Epstein‐Barr virus
  • acquired immune deficiency syndrome
  • anaplastic large cell lymphoma
  • human immunodeficiency virus
  • non‐Hodgkin lymphoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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