CD30 is a CD40-inducible molecule that negatively regulates CD40- mediated immunoglobulin class switching in non-antigen-selected human B cells

Andrea Cerutti, Andrés Schaffer, Shefali Shah, Hong Zan, Hsiou Chi Liou, Raymond G. Goodwin, Paolo Casali

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

We used our monoclonal model of germinal center maturation, CL-01 B cells, to investigate the role of CD30 in human B cell differentiation. CL- 01 cells are IgM+IgD+CD30+ and switch to IgG, IgA, and IgE when exposed to CD40L and IL-4. Switching is hampered by CD30 coengagement, possibly through interference with the CD40-mediated NF-κB-dependent transcriptional activation of downstream C(H) genes. The physiological relevance of this phenomenon is emphasized by similar CD30-mediated effects in naive B cells. Expression of CD30 by these cells is induced by CD40L but is inhibited by B cell receptor coengagement and/or exposure to IL-6 and IL-12. Our data suggest that CD30 critically regulates the CD40-mediated differentiation of non-antigen-selected human B cells.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalImmunity
Volume9
Issue number2
DOIs
StatePublished - Aug 1998

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'CD30 is a CD40-inducible molecule that negatively regulates CD40- mediated immunoglobulin class switching in non-antigen-selected human B cells'. Together they form a unique fingerprint.

Cite this