CCK/dopamine interactions in Fawn-Hooded and Wistar-Kyoto rat brain

Daniel J. Lodge, Jennifer L. Short, Linda D. Mercer, Philip M. Beart, Andrew J. Lawrence

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The aim of this study was to compare the actions of CCK neuropeptides within the nucleus accumbens (N.Acc) of alcohol preferring (Fawn-Hooded, FH) and alcohol nonpreferring (Wistar-Kyoto, WKY) rats. CCK-8S (30-300 nM) facilitated the K+ stimulated release of [3H]dopamine (DA) from N.Acc prisms in both rat strains, whereas CCK-4 (30 nM-1 μM) caused a significant decrease of evoked [3H]DA in the FH rat only. A scattered distribution of CCK-A and -B receptor immunopositive varicose fibers were visualized throughout the N.Acc of both rat strains along with a topographic distribution of CCK receptor positive cells throughout the ventral mesencephalon. (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)379-386
Number of pages8
JournalPeptides
Volume21
Issue number3
DOIs
StatePublished - Mar 1 2000
Externally publishedYes

Keywords

  • Alcohol-preferring rat
  • CCK receptors
  • Dopamine
  • Immunohistochemistry
  • Mesolimbic system
  • Nucleus accumbens

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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