CCK/dopamine interactions in Fawn-Hooded and Wistar-Kyoto rat brain

Daniel J. Lodge; Jennifer L. Short; Linda D. Mercer; Philip M. Beart; Andrew J. Lawrence

doi:10.1016/S0196-9781(00)00159-5

CCK/dopamine interactions in Fawn-Hooded and Wistar-Kyoto rat brain

Daniel J. Lodge, Jennifer L. Short, Linda D. Mercer, Philip M. Beart, Andrew J. Lawrence

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The aim of this study was to compare the actions of CCK neuropeptides within the nucleus accumbens (N.Acc) of alcohol preferring (Fawn-Hooded, FH) and alcohol nonpreferring (Wistar-Kyoto, WKY) rats. CCK-8S (30-300 nM) facilitated the K⁺ stimulated release of [³H]dopamine (DA) from N.Acc prisms in both rat strains, whereas CCK-4 (30 nM-1 μM) caused a significant decrease of evoked [³H]DA in the FH rat only. A scattered distribution of CCK-A and -B receptor immunopositive varicose fibers were visualized throughout the N.Acc of both rat strains along with a topographic distribution of CCK receptor positive cells throughout the ventral mesencephalon. (C) 2000 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	379-386
Number of pages	8
Journal	Peptides
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/S0196-9781(00)00159-5
State	Published - Mar 2000
Externally published	Yes

Keywords

Alcohol-preferring rat
CCK receptors
Dopamine
Immunohistochemistry
Mesolimbic system
Nucleus accumbens

ASJC Scopus subject areas

Endocrinology
Cellular and Molecular Neuroscience
Biochemistry
Physiology

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10.1016/S0196-9781(00)00159-5

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title = "CCK/dopamine interactions in Fawn-Hooded and Wistar-Kyoto rat brain",

abstract = "The aim of this study was to compare the actions of CCK neuropeptides within the nucleus accumbens (N.Acc) of alcohol preferring (Fawn-Hooded, FH) and alcohol nonpreferring (Wistar-Kyoto, WKY) rats. CCK-8S (30-300 nM) facilitated the K+ stimulated release of [3H]dopamine (DA) from N.Acc prisms in both rat strains, whereas CCK-4 (30 nM-1 μM) caused a significant decrease of evoked [3H]DA in the FH rat only. A scattered distribution of CCK-A and -B receptor immunopositive varicose fibers were visualized throughout the N.Acc of both rat strains along with a topographic distribution of CCK receptor positive cells throughout the ventral mesencephalon. (C) 2000 Elsevier Science Inc.",

keywords = "Alcohol-preferring rat, CCK receptors, Dopamine, Immunohistochemistry, Mesolimbic system, Nucleus accumbens",

author = "Lodge, {Daniel J.} and Short, {Jennifer L.} and Mercer, {Linda D.} and Beart, {Philip M.} and Lawrence, {Andrew J.}",

note = "Funding Information: This work was supported by the Australian Brewer{\textquoteright}s Foundation and in part by the Ramaciotti Foundation and the National Health and Medical Research Council (Australia), of which A.J. Lawrence is a RD Wright Fellow and P.M. Beart is a Senior Principal Research Fellow.",

year = "2000",

month = mar,

doi = "10.1016/S0196-9781(00)00159-5",

language = "English (US)",

volume = "21",

pages = "379--386",

journal = "Peptides",

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number = "3",

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T1 - CCK/dopamine interactions in Fawn-Hooded and Wistar-Kyoto rat brain

AU - Lodge, Daniel J.

AU - Short, Jennifer L.

AU - Mercer, Linda D.

AU - Beart, Philip M.

AU - Lawrence, Andrew J.

N1 - Funding Information: This work was supported by the Australian Brewer’s Foundation and in part by the Ramaciotti Foundation and the National Health and Medical Research Council (Australia), of which A.J. Lawrence is a RD Wright Fellow and P.M. Beart is a Senior Principal Research Fellow.

PY - 2000/3

Y1 - 2000/3

N2 - The aim of this study was to compare the actions of CCK neuropeptides within the nucleus accumbens (N.Acc) of alcohol preferring (Fawn-Hooded, FH) and alcohol nonpreferring (Wistar-Kyoto, WKY) rats. CCK-8S (30-300 nM) facilitated the K+ stimulated release of [3H]dopamine (DA) from N.Acc prisms in both rat strains, whereas CCK-4 (30 nM-1 μM) caused a significant decrease of evoked [3H]DA in the FH rat only. A scattered distribution of CCK-A and -B receptor immunopositive varicose fibers were visualized throughout the N.Acc of both rat strains along with a topographic distribution of CCK receptor positive cells throughout the ventral mesencephalon. (C) 2000 Elsevier Science Inc.

AB - The aim of this study was to compare the actions of CCK neuropeptides within the nucleus accumbens (N.Acc) of alcohol preferring (Fawn-Hooded, FH) and alcohol nonpreferring (Wistar-Kyoto, WKY) rats. CCK-8S (30-300 nM) facilitated the K+ stimulated release of [3H]dopamine (DA) from N.Acc prisms in both rat strains, whereas CCK-4 (30 nM-1 μM) caused a significant decrease of evoked [3H]DA in the FH rat only. A scattered distribution of CCK-A and -B receptor immunopositive varicose fibers were visualized throughout the N.Acc of both rat strains along with a topographic distribution of CCK receptor positive cells throughout the ventral mesencephalon. (C) 2000 Elsevier Science Inc.

KW - Alcohol-preferring rat

KW - CCK receptors

KW - Dopamine

KW - Immunohistochemistry

KW - Mesolimbic system

KW - Nucleus accumbens

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AN - SCOPUS:0034002276

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JO - Peptides

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ER -

CCK/dopamine interactions in Fawn-Hooded and Wistar-Kyoto rat brain

Abstract

Keywords

ASJC Scopus subject areas

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