Catecholamines and pinealectomy-induced convulsions in the gerbil (Meriones unguiculatus).

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Abstract

Within three hours after surgery nine out of ten pineal-ectomized gerbils will convulse; dopamine (DA) levels in the telencephalon of the gerbils do not change after pinealectomy (PX), however, norepinephrine (NE) concentrations decrease in the telencephalon from 1-12 hours after PX (Philo and Reiter, 1980). Administration of L-dihydroxyphenylalanine (L-DOPA, 50 mg/kg) will prevent the convulsions and maintain normal levels of norepinephrine. Administration of alpha-methyl-p-tyrosine (alpha MPT, 250 mg/kg), a tyrosine hydroxylase inhibitor, increases the number of convulsions. Injections of L-DOPA counter the facilitatory actions of alpha MPT on PX-induced convulsions. Studies with the monoamine oxidase inhibitor pargyline indicate a decrease in production of norepinephrine after PX in the gerbil. The diminished levels of neurotransmitter apparently facilitate the onset of convulsions caused by the epileptogenic stimulus of PX.

Original languageEnglish (US)
Pages (from-to)233-241
Number of pages9
JournalProgress in clinical and biological research
Volume92
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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