Catecholamines and Diagnoses in Children

GRAHAM A. ROGENESS, MARTIN A. JAVORS, JAMES W. MAAS, CARLOS A. MACEDO

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Theoretically, noradrenergic (NA) function may be lower in subjects with undersocialized conduct disorder (CDU) and higher in subjects with anxiety/depressive disorder. To test this hypothesis, diagnostic and 24-hour urine catecholamine measures were compared between subjects with plasma dopamine-β-hydroxylase (DβH) activities less than 6 μmoles/min/L (low DβH group) and greater than 15 μmoles/min/L (high DβH group). Several measures relating to norepinephrine metabolism were lower in the low DβH group, and the low DβH group had more diagnoses of CDU and fewer anxiety and depressive disorder diagnoses. Comparisons between clinical and biological measures within each of the DβH groups were also consistent with the hypothesized relationship between NA function, CDU, and anxiety/depressive disorder.

Original languageEnglish (US)
Pages (from-to)234-241
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume29
Issue number2
DOIs
StatePublished - Jan 1 1990

Keywords

  • catecholamines
  • conduct disorder
  • major depression
  • norepinephrine

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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