Noradrenaline (NA) and dopamine (DA) concentrations were measured in 5 discrete brain areas of barbital dependent rats following 0, 1 or 2 days of drug withdrawal. Statistically significant decreases in NA concentration were observed in the cerebral cortex and the thalamus of 1 day withdrawn rats while NA concentration in the hypothalamus was significantly reduced during the second day of withdrawal. The concentration of DA was significantly elevated in barbital dependent rats but declined following barbital withdrawal. Compared to control or nonwithdrawn rats, the concentration of DA in the thalamus was elevated by the second day of withdrawal. The changes in catecholamine concentration presumably reflect underlying effects of chronic barbital consumption or subsequent withdrawal on the synthesis, metabolism or utilization of these neurohumors.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)