Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus

John S. Albin, William L. Brown, Reuben S. Harris

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

APOBEC3 proteins are DNA cytosine deaminases that restrict the replication of human immunodeficiency virus deficient in the counterdefense protein Vif. Here, we address the capacity of APOBEC3F to restrict via deaminase-dependent and -independent mechanisms by monitoring spreading infections in diverse T cell lines. Our data indicate that only a deaminase-proficient protein is capable of long-term restriction of Vif-deficient HIV in T cells, analogous to prior reports for APOBEC3G. This indicates that the principal mechanism of APOBEC3F restriction is deaminase-dependent.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalVirology
Volume450-451
DOIs
StatePublished - Feb 2014
Externally publishedYes

Keywords

  • APOBEC3F
  • APOBEC3G
  • Deaminase
  • HIV restriction
  • Vif

ASJC Scopus subject areas

  • Virology

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