Castration reduces mortality and increases resilience in male mice: what is next?

Nisi Jiang, Catherine J. Cheng, Randy Strong, James F. Nelson

Research output: Contribution to journalComment/debatepeer-review


This commentary concerns our recent report that prepubertal castration rescued the shorter lifespan of males, using the first mouse line that robustly shows the same shorter longevity with a similar age-variable mortality disadvantage as human males. This model provides a unique opportunity for research to uncover the basis for this clinically important sex difference in aging. Researchers can now identify the hormones involved, the duration of exposure required, and, most important, the cellular and molecular targets, with the ultimate goal of developing therapeutic interventions to enhance health and reduce mortality without castration-compromising reproductive function.

Original languageEnglish (US)
Pages (from-to)2787-2790
Number of pages4
Issue number2
StatePublished - Apr 2024


  • Age-specific mortality
  • Aging
  • Castration
  • Interventions
  • Lifespan
  • Sex differences

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cardiology and Cardiovascular Medicine
  • Aging
  • Complementary and alternative medicine
  • veterinary (miscalleneous)


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